Evidence map›Paper›PMID 33236131›Full record

ReviewInternational journal of molecular medicine2021

Approaches towards fighting the COVID‑19 pandemic (Review).

Shih-Chang Tsai, Chi-Cheng Lu, Da-Tian Bau, Yu-Jen Chiu, Yu-Ting Yen, Yuan-Man Hsu, Chih-Wei Fu, Sheng-Chu Kuo, Yu-Shiang Lo, Hong-Yi Chiu and 3 more

Open access · hybridAbstract readReview
In one paragraph

Review in International journal of molecular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.

  1. Pooled it
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  19. [Impact of the COVID-19 pandemic on cardiac surgery].Zeitschrift fur Herz-, Thorax- und Gefasschirurgie · 2022
    Review
  20. [Venovenous extracorporeal membrane oxygenation for COVID-19].Zeitschrift fur Herz-, Thorax- und Gefasschirurgie · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Shih-Chang TsaiDepartment of Biological Science and Technology, China Medical University, Taichung 40402, Taiwan, R.O.C.
Chi-Cheng LuDepartment of Sport Performance, National Taiwan University of Sport, Taichung 40402, Taiwan, R.O.C.
Da-Tian BauGraduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan, R.O.C.
Yu-Jen ChiuDivision of Plastic and Reconstructive Surgery, Department of Surgery, Taipei Veteran General Hospital, Taipei 11217, Taiwan, R.O.C.
Yu-Ting YenDrug Development Center, Institute of New Drug Development, China Medical University, Taichung 40402, Taiwan, R.O.C.
Yuan-Man HsuDepartment of Biological Science and Technology, China Medical University, Taichung 40402, Taiwan, R.O.C.
Chih-Wei FuBiomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, Hsinchu 310401, Taiwan, R.O.C.
Sheng-Chu KuoSchool of Pharmacy, China Medical University, Taichung 40402, Taiwan, R.O.C.
Yu-Shiang LoDepartment of Medical Research, China Medical University Hospital, China Medical University, Taichung 40447, Taiwan, R.O.C.
Hong-Yi ChiuDepartment of Pharmacy, Buddhist Tzu Chi General Hospital, Hualien 97002, Taiwan, R.O.C.
Yu-Ning JuanDepartment of Medical Research, China Medical University Hospital, China Medical University, Taichung 40447, Taiwan, R.O.C.
Fuu-Jen TsaiSchool of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan, R.O.C.
Jai-Sing YangDepartment of Medical Research, China Medical University Hospital, China Medical University, Taichung 40447, Taiwan, R.O.C.
China Medical University · TWBuddhist Tzu Chi General Hospital · TWIndustrial Technology Research Institute · TWNational Taiwan University of Sport · TWTaipei Veterans General Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The coronavirus disease 2019 (COVID‑19) outbreak, which has caused >46 millions confirmed infections and >1.2 million coronavirus related deaths, is one of the most devastating worldwide crises in recent years. Infection with COVID‑19 results in a fever, dry cough, general fatigue, respiratory symptoms, diarrhoea and a sore throat, similar to those of acute respiratory distress syndrome. The causative agent of COVID‑19, SARS‑CoV‑2, is a novel coronavirus strain. To date, remdesivir has been granted emergency use authorization for use in the management of infection. Additionally, several efficient diagnostic tools are being actively developed, and novel drugs and vaccines are being evaluated for their efficacy as therapeutic agents against COVID‑19, or in the prevention of infection. The present review highlights the prevalent clinical manifestations of COVID‑19, characterizes the SARS‑CoV‑2 viral genome sequence and life cycle, highlights the optimal methods for preventing viral transmission, and discusses possible molecular pharmacological mechanisms and approaches in the development of anti‑SARS‑CoV‑2 therapeutic agents. In addition, the use of traditional Chinese medicines for management of COVID‑19 is discussed. It is expected that novel anti‑viral agents, vaccines or an effective combination therapy for treatment/management of SARS‑CoV‑2 infection and spread therapy will be developed and implemented in 2021, and we would like to extend our best regards to the frontline health workers across the world in their fight against COVID‑19.

Indexed as

COVID-19COVID-19 Drug TreatmentMedicine, Chinese TraditionalPandemicsSARS-CoV-2Antiviral AgentsHumansAntiviral Agents3-chymotrypsin-like cysteine proteaseacute respiratory distress syndromeangiotensin-converting enzyme 2chloroquineCOVID‑19hydroxychloroquinetraditional Chinese medicinetransmembrane protease serine 2

Identifiers

PMID33236131
PMCPMC7723515
OpenAlexW3102497717

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.