ArticleCerebral cortex (New York, N.Y. : 1991)2021
Poor Self-Reported Sleep is Related to Regional Cortical Thinning in Aging but not Memory Decline-Results From the Lifebrain Consortium.
Article in Cerebral cortex (New York, N.Y. : 1991), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 44 citations in OpenAlex.
- Association Between EAT-Lancet Diet Adherence and Sleep Quality in Lactating Women: A Cross-Sectional Analysis.Health science reports · 2026Article
- Polygenic Index for Sleep Duration and Brain Changes over Time.Medical sciences (Basel, Switzerland) · 2026Article
- Article
- Associations between objective sleep metrics and brain structure in cognitively unimpaired adults: interactions with sex and Alzheimer's biomarkers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Myelin Changes in Poor Sleepers: Insights into Glymphatic Clearance Function and Regional Circadian Clock Gene Expression.Aging and disease · 2024Article
- Poor sleep and decreased cortical thickness in veterans with mild traumatic brain injury and post-traumatic stress disorder.Military Medical Research · 2024Article
- Impaired sleep is associated with tau deposition onJournal of the neurological sciences · 2024Article
- Deficient sleep, altered hypothalamic functional connectivity, depression and anxiety in cigarette smokers.Neuroimage. Reports · 2024Article
- Shorter self-reported sleep duration is associated with worse virtual spatial navigation performance in men.Scientific reports · 2024Article
- FEMA: Fast and efficient mixed-effects algorithm for large sample whole-brain imaging data.Human brain mapping · 2024Article
- No phenotypic or genotypic evidence for a link between sleep duration and brain atrophy.Nature human behaviour · 2023Article
- Causal associations between sleep traits and brain structure: a bidirectional Mendelian randomization study.Behavioral and brain functions : BBF · 2023Article
- Is Short Sleep Bad for the Brain? Brain Structure and Cognitive Function in Short Sleepers.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Purpose in life promotes resilience to age-related brain burden in middle-aged adults.Alzheimer's research & therapy · 2023Article
- Associations between self-reported sleep patterns and health, cognition and amyloid measures: results from the Wisconsin Registry for Alzheimer's Prevention.Brain communications · 2023Article
- The association between inadequate sleep and accelerated brain ageing.Neurobiology of aging · 2022Article
- Human Brain Resilience: A Call to Action.Annals of neurology · 2021Review
- The genetic organization of longitudinal subcortical volumetric change is stable throughout the lifespan.eLife · 2021Article
- The Relation of Sleep Characteristics and Cognitive Impairment in Community-Dwelling Middle-Aged and Older Adults: Ardakan Cohort Study on Aging (ACSA).Dementia and geriatric cognitive disorders extraArticle
Corrections and comments
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Authors and funding
32 authors at 15 institutions in 8 countries.
Funding
Abstract
We examined whether sleep quality and quantity are associated with cortical and memory changes in cognitively healthy participants across the adult lifespan. Associations between self-reported sleep parameters (Pittsburgh Sleep Quality Index, PSQI) and longitudinal cortical change were tested using five samples from the Lifebrain consortium (n = 2205, 4363 MRIs, 18-92 years). In additional analyses, we tested coherence with cell-specific gene expression maps from the Allen Human Brain Atlas, and relations to changes in memory performance. "PSQI # 1 Subjective sleep quality" and "PSQI #5 Sleep disturbances" were related to thinning of the right lateral temporal cortex, with lower quality and more disturbances being associated with faster thinning. The association with "PSQI #5 Sleep disturbances" emerged after 60 years, especially in regions with high expression of genes related to oligodendrocytes and S1 pyramidal neurons. None of the sleep scales were related to a longitudinal change in episodic memory function, suggesting that sleep-related cortical changes were independent of cognitive decline. The relationship to cortical brain change suggests that self-reported sleep parameters are relevant in lifespan studies, but small effect sizes indicate that self-reported sleep is not a good biomarker of general cortical degeneration in healthy older adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.