ArticleCritical care explorations2020
Advanced Respiratory Support in the Contemporary Cardiac ICU.
Article in Critical care explorations, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 43 citations in OpenAlex.
- Association between Respiratory Failure and Clinical Outcomes in Patients with Acute Heart Failure: Analysis of 5 Pooled Clinical Trials.Journal of cardiac failure · 2021Trial
- Hemodynamic Effects of Anesthetics, Sedatives, and Analgesics in the CICU: Clinical Decision Guidance.JACC. Advances · 2026Review
- Beyond Respiratory Support: Clinical Profiles and Factors Associated with Mortality in Heart Failure Patients Admitted to the ICU.Journal of clinical medicine · 2026Article
- Experts' recommendations for the management of adult patients with cardiogenic shock.Annals of intensive care · 2026Article
- Respiratory Support and Mortality Risk Across the Spectrum of Cardiogenic Shock Severity.Journal of the Society for Cardiovascular Angiography & Interventions · 2025Article
- Navigating Hypoxemic Respiratory Failure in Critically Ill Cardiac Patients.JACC. Advances · 2025Review
- Management Patterns and Outcomes of Invasive Mechanical Ventilation in Patients With Cardiogenic Shock.JACC. Advances · 2025Article
- Moving From the Epidemiology to the Treatment of Respiratory Failure in Patients With Cardiogenic Shock.JACC. Advances · 2025Article
- Management of non-Cardiac Organ Failure in cardiogenic shock.American heart journal plus : cardiology research and practice · 2025Article
- Underrepresentation and exclusion of patients with cardiovascular disease in intensive care randomized controlled trials.European heart journal. Acute cardiovascular care · 2025Article
- Hepatic Biomarker Abnormalities in the Cardiac Intensive Care Unit: Proposed Criteria for Cardiohepatic Syndrome.JACC. Advances · 2025Article
- Acute Decompensated Valvular Disease in the Intensive Care Unit.JACC. Advances · 2024Review
- Comparing Outcomes Between Advanced Practice Providers and Housestaff Teams in the Cardiac Intensive Care Unit.JACC. Advances · 2024Article
- Ventilation strategies in cardiogenic shock: Insights from the AltShock-2 registry.European journal of heart failure · 2024Article
- Outcomes for Mechanically Ventilated Patients With Acute Myocardial Infarction Admitted to Medical vs Cardiac Intensive Care Units.JACC. Advances · 2024Article
- Research Priorities in Critical Care Cardiology: JACC Expert Panel.Journal of the American College of Cardiology · 2023Review
- Clinical Predictors and Outcomes After Left Ventricular Assist Device Implantation and Tracheostomy.Texas Heart Institute journal · 2023Article
- Rocuronium Versus Succinylcholine in Patients With Acute Myocardial Infarction Requiring Mechanical Ventilation.Journal of the American Heart Association · 2023Article
- Liberation From Mechanical Ventilation in the Cardiac Intensive Care Unit.JACC. Advances · 2023Review
- Critical Care Cardiology Trials Network (CCCTN): a cohort profile.European heart journal. Quality of care & clinical outcomes · 2022Article
Corrections and comments
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Authors and funding
18 authors at 13 institutions in 2 countries.
Funding
Abstract
The medical complexity and critical care needs of patients admitted to cardiac ICUs are increasing, and prospective studies examining the underlying cardiac and noncardiac diagnoses, the management strategies, and the prognosis of cardiac ICU patients with respiratory failure are needed.
designProspective cohort study.
settingThe Critical Care Cardiology Trials Network is a research collaborative of cardiac ICUs across the United States and Canada. PATIENTS: We included all medical cardiac ICU admissions at 25 cardiac ICUs during two consecutive months annually at each center from 2017 to 2019. MEASUREMENTS: We evaluated the use of advanced respiratory therapies including invasive mechanical ventilation, noninvasive ventilation, and high-flow nasal cannula versus no advanced respiratory support across admission diagnoses and the association with in-hospital mortality. MAIN
resultsOf 8,240 cardiac ICU admissions, 1,935 (23.5%) were treated with invasive mechanical ventilation, 573 (7.0%) with noninvasive ventilation, and 281 (3.4%) with high-flow nasal cannula. Admitting diagnoses among those with advanced respiratory support were diverse including general medical problems in patients with heart disease as well as primary cardiac problems. In-hospital mortality was higher in patients who received invasive mechanical ventilation (38.1%; adjusted odds ratio, 2.53; 2.02-3.16) and noninvasive ventilation or high-flow nasal cannula (8.8%; adjusted odds ratio, 2.25; 1.73-2.93) compared with patients without advanced respiratory support (4.6%). Reintubation rate was 7.6%. The most common variables associated with respiratory insufficiency included heart failure, infection, chronic obstructive pulmonary disease, and pulmonary vascular disease.
conclusionsOne-third of cardiac ICU admissions receive respiratory support with associated increased mortality. These data provide benchmarks for quality improvement ventures in the cardiac ICU, inform cardiac critical care training and staffing patterns, and serve as foundation for future studies aimed at improving outcomes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.