ArticleIranian journal of basic medical sciences2020
An effective weapon against biofilm consortia and small colony variants of MRSA.
Article in Iranian journal of basic medical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Formation of COBiofilm · 2025Article
- Suppression ofIranian journal of basic medical sciences · 2024Article
- Silicon nanoparticles: A promising approach for control ofIranian journal of basic medical sciences · 2023Article
- Characteristics of Staphylococcus aureus small colony variants isolated from wound specimen of a tertiary care hospital in China.Journal of clinical laboratory analysis · 2022Article
- Staphylococcal Infections: Host and Pathogenic Factors.Microorganisms · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study was designed to investigate the effect of AgNPs (10 nm and 30 nm) on different phenotypes of MATERIALS AND
methodsA total of eighteen biofilm-producing isolates of Methicillin-Resistant
resultsResults showed that biofilm consortia harbour different phenotypes, i.e., planktonic, metabolically inactive cells, and small colony variants (SCVs) or persister cells. The focus of the present study is the effect of AgNPs on biofilm consortia of MRSA, particularly on the SCVs population. Large size AgNPs (30 nm) were unable to diffuse through extracellular matrix material coverings of the biofilm consortia; they were only active against the planktonic population that occupies the outer surface of consortia. The smaller AgNPs (10 nm), on the other hand, were found to diffuse through the matrix material and hence were effective against planktonic as well as metabolically inactive population of consortia. Moreover, 30 nm AgNPs take 6 hr to disperse off and kill planktonic and upper surface indwellers. The 10 nm AgNPs disperse and kill the majority of biofilm indwellers within 20 min.
conclusionThe present study showed that 10 nm AgNPs can easily penetrate inside the biofilm and are active against all of the indwellers of consortia.
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