Evidence map›Paper›PMID 33235699›Full record

ArticleIranian journal of basic medical sciences2020

MicroRNA-155 from sputum as noninvasive biomarker for diagnosis of active pulmonary tuberculosis.

Hua Ying, Sun FengYing, Wu YanHong, Huang YouMing, Zhou FaYou, Zhang HongXiang, Tang XiaoLei

Open access · greenAbstract read
In one paragraph

Article in Iranian journal of basic medical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
0.6field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Review
  7. Journal of clinical tuberculosis and other mycobacterial diseases · 2024
    Review
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Hua YingVascular Disease Research Center and Basic Medical Laboratory, the Second Affiliated Hospital of Wannan Medical College, Kangfu Road 10#, Wuhu 241000, Anhui Province, PR China.
Sun FengYingDepartment of Clinical Laboratory, the Second Peoples' Hospital of Wuhu city, Jiuhua Zhong Road 259#, Wuhu 241000, Anhui Province, PR China.
Wu YanHongDepartment of Microbiology, Wannan Medical College, Wenchang Xi Road 22#, Wuhu 241000, Anhui Province, PR China.
Huang YouMingVascular Disease Research Center and Basic Medical Laboratory, the Second Affiliated Hospital of Wannan Medical College, Kangfu Road 10#, Wuhu 241000, Anhui Province, PR China.
Zhou FaYouVascular Disease Research Center and Basic Medical Laboratory, the Second Affiliated Hospital of Wannan Medical College, Kangfu Road 10#, Wuhu 241000, Anhui Province, PR China.
Zhang HongXiangVascular Disease Research Center and Basic Medical Laboratory, the Second Affiliated Hospital of Wannan Medical College, Kangfu Road 10#, Wuhu 241000, Anhui Province, PR China.
Tang XiaoLeiVascular Disease Research Center and Basic Medical Laboratory, the Second Affiliated Hospital of Wannan Medical College, Kangfu Road 10#, Wuhu 241000, Anhui Province, PR China.
Wannan Medical College · CNWuhu Fourth People Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTuberculosis (TB), caused by MATERIALS AND

methodsThe

resultsOnly miR-155 showed a better diagnostic value for PTB than the other five miRNAs to distinguish PTB from non-PTB, including pneumonia, lung cancer, and unexplained pulmonary nodules. Next, we detected and analyzed the results of 68 PTB patients and 122 non-PTB, the sensitivity and specificity of miR-155 detection was 94.1% and 87.7%, respectively. It was higher than sputum smear detection and anti-TB antibody detection. But slightly lower than ELISpot (97%,

conclusionOur research suggested that miR-155 may be an efficiency biomarker for active PTB diagnosis and bacteria-loads evaluation.

Indexed as

BiomarkerDiagnosismicroRNA-155Pulmonary tuberculosisSputum

Identifiers

PMID33235699
PMCPMC7671418
OpenAlexW3093386604

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.