ArticlePakistan journal of medical sciences
Study on the Correlation between Metabolism, Insulin Sensitivity and progressive weight loss change in Type-2 Diabetes.
Article in Pakistan journal of medical sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- A Pharmacometric Method for Quantitative Determination of Improvement in Body Composition and Characterization of the Exposure-Response Relationship during Treatment of Obesity with Tirzepatide.Clinical pharmacology and therapeutics · 2025Trial
- The Impact of Digital Self-Monitoring of Weight on Improving Diabetes Clinical Outcomes: Quasi-Randomized Study.Journal of medical Internet research · 2024Trial
- Supernatants from Water Extraction-Ethanol Precipitation ofFoods (Basel, Switzerland) · 2026Article
- GLM-DM: language model boosted neural networks for HbA1c trend prediction in diabetes mellitus.Future science OA · 2025Article
- Maternal ingestion of cannabidiol (CBD) in mice leads to sex-dependent changes in memory, anxiety, and metabolism in the adult offspring, and causes a decrease in survival to weaning age.Pharmacology, biochemistry, and behavior · 2025Article
- Comparison of the effects of losartan potassium and benazepril in the treatment of hypertensive patients with insulin resistance.Pakistan journal of medical sciences · 2024Article
- Effect of Gegen Qinlian Decoction combined with dietary management on patients with damp-heat Type-2 diabetes mellitus and metabolic syndrome.Pakistan journal of medical sciences · 2024Article
- The effects of dietary intervention combined with comprehensive exercise instruction on somatic function and quality of life in elderly patients with diabetes mellitus.Pakistan journal of medical sciences · 2024Article
- Effects of motivational interviewing intervention on psychological status, compliance behavior and quality of life of patients with malignant tumor combined with diabetes mellitus.Pakistan journal of medical sciences · 2024Article
- Assessment of eating habits, lifestyle and physical activity among medical and dental students of Faisalabad Medical University.Pakistan journal of medical sciencesArticle
- Clinical Efficacy of Bolus of Six Drugs Including Rehmannia as an Adjunct to Metformin in the Treatment of Senile Type-2 Diabetes Mellitus and its Influence on Insulin Resistance, Inflammatory Factors and Blood Glucose-related Indicators.Pakistan journal of medical sciencesArticle
- Malnutrition among patients with Type-2 Diabetes Mellitus.Pakistan journal of medical sciencesArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
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Abstract
objectiveTo observe the changes of lipid metabolism, blood glucose level and insulin sensitivity in patients with Type-2 diabetes after progressive weight loss of their body weight, so as to lay a theoretical foundation for diabetes treatment and education in the future.
methodsOne hundred obese patients with Type-2 diabetes (BMI ≥ 25 kg/m
resultsWith the decrease of body weight, the differences of TC, TG, LDL-C and HDL-C at different weight loss points were significant (p < 0.05), and the changes of fasting blood glucose in 5% and 10% weight loss were significant (p = 0.02). The 2h postprandial blood glucose showed the most significant difference when the weight loss reached 15% (p = 0.00). There was no statistical difference in the change of glycosylated hemoglobin among different weight loss points (p = 0.08). When the weight loss reached 10%, the blood insulin level was significantly lower than that before the weight loss, while the insulin level was not significantly changed when the weight loss reached 15%, but the peak of secretion was shifted forward. It is suggested that insulin sensitivity gradually increases with weight loss.
conclusionObese patients with Type-2 diabetes can benefit from weight loss, with abnormal blood glucose and lipid metabolism improved, insulin resistance relieved, and insulin sensitivity increased.
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