ArticlePakistan journal of medical sciences
Letrozole is superior to clomiphene citrate in ovulation induction in patients with polycystic ovary syndrome.
Article in Pakistan journal of medical sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Investigation of trends, hot spots and effective therapies for pregnancy outcomes in polycystic ovary syndrome: a bibliometric analysis.Frontiers in medicine · 2026Pooled it
- Letrozole at the Crossroads of Efficacy and Fetal Safety in Ovulation Induction: A Narrative Review.Biomedicines · 2025Review
- Effect of individualized psychological interventions on the psychological state and pregnancy outcomes of patients with recurrent spontaneous abortion.Pakistan journal of medical sciences · 2025Article
- Value analysis of serum β -HCG, AMH, and P/EPakistan journal of medical sciences · 2025Article
- Efficacy of probiotics combined with metformin and a calorie-restricted diet in obese patients with polycystic ovary syndrome.Pakistan journal of medical sciences · 2025Article
- Influencing factors of polyspermy during in vitro fertilization with antagonist protocol.Pakistan journal of medical sciences · 2025Article
- Strong Early Impact of Letrozole on Ovulation Induction Outperforms Clomiphene Citrate in Polycystic Ovary Syndrome.Pharmaceuticals (Basel, Switzerland) · 2024Review
- The effect of Bushenhuoxue nutritional decoction in the treatment of overweight patients with polycystic ovarian syndrome.Pakistan journal of medical sciences · 2024Article
- Current Ovulation and Luteal Phase Tracking Methods and Technologies for Fertility and Family Planning: A Review.Seminars in reproductive medicine · 2024Review
- Effect of follicle size on pregnancy outcomes in patients undergoing first letrozole-intrauterine insemination.European journal of medical research · 2024Article
- Article
- LetrozoleHeliyon · 2023Article
- Hormonal and Metabolic Factors Influence the Action of Progesterone on the Endometrium of Women with Polycystic Ovary Syndrome.Diagnostics (Basel, Switzerland) · 2023Article
- Hypothalamic-Pituitary-Gonadal Axis Disorders Impacting Fertility in Both Sexes and the Potential of Kisspeptin-Based Therapies to Treat Them.Handbook of experimental pharmacology · 2023Review
- A comparative study between Dydrogesterone alone and combined with Non-Steroidal Anti-Inflammatory Drugs in the treatment of Mild Endometriosis.Pakistan journal of medical sciencesArticle
- Correlation between Triclosan (TCS) exposure and endometriosis.Pakistan journal of medical sciencesArticle
- Efficacy of Letrozole vs Clomiphene Citrate for induction of ovulation in women with polycystic ovarian syndrome.Pakistan journal of medical sciencesArticle
- Efficacy of letrozole versus clomiphene citrate on ovulation induction in patients with polycystic ovarian syndrome.Pakistan journal of medical sciencesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study was aimed to compare the clinical outcomes of ovulation induction (OI) by timed intercourse with letrozole (LTZ) and clomiphene citrate (CC).
methodsThree hundred and twenty-three patients with polycystic ovary syndrome (PCOS) who underwent OI with LTZ or CC between February 2017 and November 2018 were included in this retrospective study. The patients were divided into two groups as the CC group (n=148) and the LTZ group (n=175). Endometrial thickness, follicular development, ovulation, clinical pregnancy, abortion, and live birth rates of the groups were analyzed.
resultsThe mean endometrium thickness of the CC group was 7.1±1.7 mm, and the LTZ group was 8.6±1.8 mm (p<0.001). The ovulation rate per cycle was higher in the LTZ group (93.1%) in comparison with the CC group (83.8%) (p=0.013). Clinical pregnancy rates were 52% in the LTZ group, and 41.2% in the CC group (p=0.047). LTZ with 44% of live birth rate was superior to CC with a 33% live birth rate (p=0.029).
conclusionsLTZ is an effective OI agent in PCOS patients. LTZ is superior to CC in terms of pregnancy rates and live birth rates. As a result, we recommend that LTZ should be the first-line treatment agent in patients with PCOS.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.