Evidence map›Paper›PMID 33235417›Full record

ArticleActa Cardiologica Sinica2020

Sex Differences in the Mortality Risk of Elderly Patients with Systolic Heart Failure in Taiwan.

Tsung-Jui Wu, Gen-Min Lin, Chin-Sheng Lin, Pang-Yen Liu, Kuan-Jen Su, Chia-Chang Lin, Tzu-Chiao Lin, Shu-Meng Cheng, Shih-Hua Lin, Eiki Takimoto and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta Cardiologica Sinica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Tsung-Jui WuDepartment of Medicine, Hualien Armed Forces General Hospital, Hualien.
Gen-Min LinDepartment of Medicine, Hualien Armed Forces General Hospital, Hualien.
Chin-Sheng LinDivision of Cardiology, Departments of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Pang-Yen LiuDivision of Cardiology, Departments of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Kuan-Jen SuDivision of Cardiology, Departments of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Chia-Chang LinDivision of Cardiology, Departments of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Tzu-Chiao LinDivision of Cardiology, Departments of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Shu-Meng ChengDivision of Cardiology, Departments of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Shih-Hua LinDivision of Nephrology.
Eiki TakimotoDepartment of Cardiovascular Medicine, School of Medicine, The University of Tokyo, Tokyo, Japan.
Issei KomuroDepartment of Cardiovascular Medicine, School of Medicine, The University of Tokyo, Tokyo, Japan.
Wei-Shiang LinDivision of Cardiology, Departments of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
The University of Tokyo · JPHualien Armed Forces General Hospital · TWKaohsiung Armed Forces General Hospital · TWTaichung Armed Forces General Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSex differences in heart failure mortality might be affected by age, race, and treatment response. Many large studies in Western countries have shown conflicting results, however few studies have been conducted in Asian patients.

objectivesWe prospectively investigated the mortality risk in a multicenter cohort of 1,093 male and 416 female heart failure patients with reduced ejection fraction (HFrEF) hospitalized for worsening symptoms in Taiwan between 2013 and 2015.

methodsKaplan-Meier curve and Cox proportional regression analyses were used to determine the one-year mortality risk by sex.

resultsThere were no significant differences in major adverse cardiovascular events, re-admission rate, and mortality between sexes in the overall cohort and the young subgroup during one-year of follow-up. In the elderly subgroup, the overall and cardiac mortality rate of the male patients were higher than those of the female patients (p = 0.035, p = 0.049, respectively). We found that the prognostic effect of old age on overall mortality rate appeared to be stronger in the male patients (p < 0.0001) than in the female patients (p = 0.69) in Cox regression analysis and Kaplan-Meier survival curves. Male sex was a risk factor for all-cause mortality in the elderly (hazard ratio: 1.50, 95% confidence interval 1.02-2.25) independently of systolic blood pressure, diabetes mellitus, hemoglobin concentration, kidney function, and medications.

conclusionsIn the Taiwan HFrEF registry, the highest mortality risk was observed in male patients aged 65 years or more. Clinicians need to pay more attention to these patients.

Indexed as

AgeHeart failureMortalitySex difference

Identifiers

PMID33235417
PMCPMC7677635
OpenAlexW3109383875

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.