Evidence map›Paper›PMID 33235413›Full record

ReviewActa Cardiologica Sinica2020

Management of Pulmonary Arterial Hypertension Patients with World Health Organization Functional Class II.

Cheng-Chung Hung, Chin-Chang Cheng, Wei-Chun Huang, Kun-Chang Lin, Feng-Yu Kuo, Shu-Hung Kuo, Tse-Hsuan Yang, Hsin-Li Liang, Guang-Yuan Mar

Abstract readReview
In one paragraph

Review in Acta Cardiologica Sinica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Cheng-Chung HungDepartment of Critical Care Medicine, Kaohsiung Veterans General Hospital, Kaohsiung.
Chin-Chang ChengDepartment of Critical Care Medicine, Kaohsiung Veterans General Hospital, Kaohsiung.
Wei-Chun HuangDepartment of Critical Care Medicine, Kaohsiung Veterans General Hospital, Kaohsiung.
Kun-Chang LinDepartment of Critical Care Medicine, Kaohsiung Veterans General Hospital, Kaohsiung.
Feng-Yu KuoDepartment of Critical Care Medicine, Kaohsiung Veterans General Hospital, Kaohsiung.
Shu-Hung KuoDepartment of Critical Care Medicine, Kaohsiung Veterans General Hospital, Kaohsiung.
Tse-Hsuan YangDepartment of Critical Care Medicine, Kaohsiung Veterans General Hospital, Kaohsiung.
Hsin-Li LiangDepartment of Critical Care Medicine, Kaohsiung Veterans General Hospital, Kaohsiung.
Guang-Yuan MarDepartment of Critical Care Medicine, Kaohsiung Veterans General Hospital, Kaohsiung.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pulmonary arterial hypertension (PAH) is an incurable chronic and progressive debilitating disease associated with significant morbidity and mortality. The World Health Organization functional class (WHO FC) at diagnosis and at follow-up remains one of the strongest predictors of survival in PAH. Studies have shown improved long-term outcomes in PAH patients who received PAH-specific treatment, as monotherapy or as combination therapy, early in their disease course. Studies have also shown that without treatment, PAH rapidly deteriorates even in patients with less advanced (low risk) disease state. In this article, we review evidence from randomized controlled clinical trials to support our position on the importance of early PAH management in WHO FC II patients. The growing importance of combination therapy in the early treatment of PAH and recommendations by the most recent guidelines for the diagnosis and treatment of pulmonary hypertension are also discussed in this article.

Indexed as

Early treatmentPulmonary artery hypertensionWorld Health Organization Functional Class

Identifiers

PMID33235413
PMCPMC7677643

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.