Evidence map›Paper›PMID 33235273›Full record

ArticleScientific reports2020

High CD45 expression of CD8+ and CD4+ T cells correlates with the size of HIV-1 reservoir in blood.

Stefan Petkov, Yonas Bekele, Tadepally Lakshmikanth, Bo Hejdeman, Maurizio Zazzi, Petter Brodin, Francesca Chiodi

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Advances in HIV Research Using Mass Cytometry.Current HIV/AIDS reports · 2023
    Review
  5. Article
  6. Article
  7. Assessment of hepatitis E seropositivity among HIV-infected patients in Bulgaria.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Stefan PetkovDepartment of Microbiology, Tumor and Cell Biology, Biomedicum, Karolinska Institutet, Solna vägen 9, 17165, Solna, Stockholm, Sweden.
Yonas BekeleDepartment of Microbiology, Tumor and Cell Biology, Biomedicum, Karolinska Institutet, Solna vägen 9, 17165, Solna, Stockholm, Sweden.
Tadepally LakshmikanthDivision of Clinical Pediatrics, Department of Women's and Children's Health, Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden.
Bo HejdemanDepartment of Clinical Science and Education, Södersjukhuset, Unit of Infectious Diseases, Venhälsan, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
Maurizio ZazziDepartment of Microbiology and Virology, Policlinico S. Maria Alle Scotte, Siena, Italy.
Petter BrodinDivision of Clinical Pediatrics, Department of Women's and Children's Health, Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden.
Francesca ChiodiDepartment of Microbiology, Tumor and Cell Biology, Biomedicum, Karolinska Institutet, Solna vägen 9, 17165, Solna, Stockholm, Sweden. francesca.chiodi@ki.se.
Karolinska Institutet · SEOspedale Santa Maria alle Scotte · ITScience for Life Laboratory · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Using mass cytometry, we investigated the expression of 28 markers on CD8+ and CD4+ T cells from HIV-1 infected patients with a variable size of HIV-1 reservoir defined as high (HR) and low (LR) reservoir; we aimed at identifying phenotypic associations of T cells with size of HIV-1 reservoir. We showed that the frequency of CD45+ CD8+ and CD4+ T cells was directly proportional to the size of HIV-1 reservoir; HR patients had a significantly larger frequency of blood CD45

Indexed as

BloodCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCytokinesFemaleFlow CytometryHIV-1HIV InfectionsHumansLeukocyte Common AntigensMaleProgrammed Cell Death 1 ReceptorRNA, ViralUp-RegulationViral LoadCytokinesLeukocyte Common AntigensPDCD1 protein, humanProgrammed Cell Death 1 ReceptorPTPRC protein, humanRNA, Viral

Identifiers

PMID33235273
PMCPMC7686502
OpenAlexW3108221444

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.