ArticleScientific reports2020
Sustainable drug release from polycaprolactone coated chitin-lignin gel fibrous scaffolds.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Electrospun core-shell nanofibres embedding drug nanocrystals for long-acting mucosal delivery.Materials today. Bio · 2026Article
- Sex-based differences in cell migration on aligned topographies.Scientific reports · 2025Article
- Current State of Knowledge Regarding the Treatment of Cranial Bone Defects: An Overview.Materials (Basel, Switzerland) · 2025Review
- Trends in Photopolymerization 3D Printing for Advanced Drug Delivery Applications.Biomacromolecules · 2025Review
- Recent advances in coaxial electrospun nanofibers for wound healing.Materials today. Bio · 2024Review
- Article
- Computational evaluation of zirconocene catalysts for ε-caprolactone cationic ring-opening polymerization.Scientific reports · 2024Article
- Development of progesterone electrospun nanofibers to coat Arabin pessaries as a dual preventive and therapeutic approach for preterm labor.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024Article
- Lignins as Promising Renewable Biopolymers and Bioactive Compounds for High-Performance Materials.Polymers · 2023Review
- Lignin, the Lignification Process, and Advanced, Lignin-Based Materials.International journal of molecular sciences · 2023Review
- Temperature-Responsive Hydrogel for Silver Sulfadiazine Drug Delivery: Optimized Design and In Vitro/In Vivo Evaluation.Gels (Basel, Switzerland) · 2023Article
- Designing Lignin-Based Biomaterials as Carriers of Bioactive Molecules.Pharmaceutics · 2023Review
- Cellulose and Lignin-Derived Scaffold and Their Biological Application in Tissue Engineering, Drug Delivery, and Wound Healing: A Review.Cell journal · 2023Article
- Hybrid Manufacturing of Oral Solid Dosage Forms via Overprinting of Injection-Molded Tablet Substrates.Pharmaceutics · 2023Article
- Designing Silk-Based Cryogels for Biomedical Applications.Biomimetics (Basel, Switzerland) · 2022Review
- Biomaterials for Tissue Engineering Applications and Current Updates in the Field: A Comprehensive Review.AAPS PharmSciTech · 2022Review
- Dual-Functional Nanofibrous Patches for Accelerating Wound Healing.International journal of molecular sciences · 2022Article
- Review
- Colloidal multiscale porous adhesive (bio)inks facilitate scaffold integration.Applied physics reviews · 2021Article
- An Additively Manufactured Sample Holder to Measure the Controlled Release of Vancomycin from Collagen Laminates.Biomedicines · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Non-healing wounds have placed an enormous stress on both patients and healthcare systems worldwide. Severe complications induced by these wounds can lead to limb amputation or even death and urgently require more effective treatments. Electrospun scaffolds have great potential for improving wound healing treatments by providing controlled drug delivery. Previously, we developed fibrous scaffolds from complex carbohydrate polymers [i.e. chitin-lignin (CL) gels]. However, their application was limited by solubility and undesirable burst drug release. Here, a coaxial electrospinning is applied to encapsulate the CL gels with polycaprolactone (PCL). Presence of a PCL shell layer thus provides longer shelf-life for the CL gels in a wet environment and sustainable drug release. Antibiotics loaded into core-shell fibrous platform effectively inhibit both gram-positive and -negative bacteria without inducting observable cytotoxicity. Therefore, PCL coated CL fibrous gel platforms appear to be good candidates for controlled drug release based wound dressing applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.