ArticleScientific reports2020
Elucidating nanoscale mechanical properties of diabetic human adipose tissue using atomic force microscopy.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- A Systematic Review of Submetatarsal Fat Pad Augmentation for the Treatment and Prevention of Diabetes-Related Foot Ulceration.Journal of foot and ankle research · 2025Pooled it
- Microengineered Gradient Hydrogels for Mechanobiology.Advanced healthcare materials · 2026Review
- Obesity and Cancer: From Systemic Metabolic Reprogramming to Immunotherapy Paradox.Metabolites · 2026Review
- A Hydrogel Culture System Regulates Human Adipocyte Function.International journal of molecular sciences · 2025Article
- Heterogeneity in cranial dura mater at the microscale: An In-situ and ex-vivo structural and mechanical investigation of sulcus and gyrus Dura.Acta biomaterialia · 2025Article
- Advances and challenges in decellularized adipose tissue based composite hydrogels for adipose tissue regeneration: a review over the last fifteen years.Theranostics · 2025Review
- Combined effects of matrix stiffness and obesity-associated signaling directs progressive phenotype in PANC-1 pancreatic cancer cellsbioRxiv : the preprint server for biology · 2024Article
- Mechanobiology of Adipocytes.Biology · 2024Review
- Characterizing morphological alterations in blood related disorders through Atomic Force Microscopy.Nanotheranostics · 2024Review
- Matrix density regulates adipocyte phenotype.Adipocyte · 2023Article
- Review
- Adipose cells and tissues soften with lipid accumulation while in diabetes adipose tissue stiffens.Scientific reports · 2022Article
- Rho/ROCK mechanosensor in adipocyte stiffness and traction force generation.Biochemical and biophysical research communications · 2022Article
- Tissue-mimetic culture enhances mesenchymal stem cell secretome capacity to improve regenerative activity of keratinocytes and fibroblasts in vitro.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair SocietyArticle
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Obesity-related type 2 diabetes (DM) is a major public health concern. Adipose tissue metabolic dysfunction, including fibrosis, plays a central role in DM pathogenesis. Obesity is associated with changes in adipose tissue extracellular matrix (ECM), but the impact of these changes on adipose tissue mechanics and their role in metabolic disease is poorly defined. This study utilized atomic force microscopy (AFM) to quantify difference in elasticity between human DM and non-diabetic (NDM) visceral adipose tissue. The mean elastic modulus of DM adipose tissue was twice that of NDM adipose tissue (11.50 kPa vs. 4.48 kPa) to a 95% confidence level, with significant variability in elasticity of DM compared to NDM adipose tissue. Histologic and chemical measures of fibrosis revealed increased hydroxyproline content in DM adipose tissue, but no difference in Sirius Red staining between DM and NDM tissues. These findings support the hypothesis that fibrosis, evidenced by increased elastic modulus, is enhanced in DM adipose tissue, and suggest that measures of tissue mechanics may better resolve disease-specific differences in adipose tissue fibrosis compared with histologic measures. These data demonstrate the power of AFM nanoindentation to probe tissue mechanics, and delineate the impact of metabolic disease on the mechanical properties of adipose tissue.
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Registered trials
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