ArticleScientific reports2020
The effect of time since stroke, gender, age, and lesion size on thalamus volume in chronic stroke: a pilot study.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- Somatosensory Deficits After Stroke: Insights From MRI Studies.Frontiers in neurology · 2022Pooled it
- Exploring Gray Matter Alterations in Post-Stroke Patients: A Structural Covariance Analysis.Brain and behavior · 2026Article
- Secondary thalamic dysfunction underlies abnormal large-scale neural dynamics in chronic stroke.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Article
- SynthSR: A public AI tool to turn heterogeneous clinical brain scans into high-resolution T1-weighted images for 3D morphometry.Science advances · 2023Article
- ASL MRI informs blood flow to chronic stroke lesions in patients with aphasia.Frontiers in physiology · 2023Article
- Volume reduction without neuronal loss in the primate pulvinar complex following striate cortex lesions.Brain structure & function · 2021Article
- The Role of the Thalamus in Declarative and Procedural Linguistic Memory Processes.Frontiers in psychology · 2021Review
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Authors and funding
26 authors at 15 institutions in 1 country.
Funding
Abstract
Recent stroke studies have shown that the ipsi-lesional thalamus longitudinally and significantly decreases after stroke in the acute and subacute stages. However, additional considerations in the chronic stages of stroke require exploration including time since stroke, gender, intracortical volume, aging, and lesion volume to better characterize thalamic differences after cortical infarct. This cross-sectional retrospective study quantified the ipsilesional and contralesional thalamus volume from 69 chronic stroke subjects' anatomical MRI data (age 35-92) and related the thalamus volume to time since stroke, gender, intracortical volume, age, and lesion volume. The ipsi-lesional thalamus volume was significantly smaller than the contra-lesional thalamus volume (t(68) = 13.89, p < 0.0001). In the ipsilesional thalamus, significant effect for intracortical volume (t(68) = 2.76, p = 0.008), age (t(68) = 2.47, p = 0.02), lesion volume (t(68) = - 3.54, p = 0.0008), and age*time since stroke (t(68) = 2.46, p = 0.02) were identified. In the contralesional thalamus, significant effect for intracortical volume (t(68) = 3.2, p = 0.002) and age (t = - 3.17, p = 0.002) were identified. Clinical factors age and intracortical volume influence both ipsi- and contralesional thalamus volume and lesion volume influences the ipsilesional thalamus. Due to the cross-sectional nature of this study, additional research is warranted to understand differences in the neural circuitry and subsequent influence on volumetrics after stroke.
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