SynthesisJournal of clinical gastroenterology2021
Probiotics for the Prevention of Antibiotic-associated Diarrhea in Adults: A Meta-Analysis of Randomized Placebo-Controlled Trials.
Synthesis in Journal of clinical gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- Probiotic-Driven Competitive Exclusion in the Human Gut: A Meta-Analysis of Microbial Diversity and Pathogen Suppression.Nutrients · 2026Pooled it
- Impact of postoperative dairy consumption on oral wound healing: critical analysis from a prospective, randomized and controlled trial.Head & face medicine · 2025Trial
- High-dose Probiotic Mix ofOpen forum infectious diseases · 2024Trial
- Probiotic and Technological Potential of Enterococcus faecium EM03, Isolated From Brazilian Semi-hard Cheese.Probiotics and antimicrobial proteins · 2026Article
- Oral antibiotics prescribing patterns and associated diarrhea risk: Public health implications.Journal of public health research · 2026Article
- The Regulating Effect of Weizmannia coagulans BC-G44 on Antibiotic-Associated Diarrhea and its Improvement on Gut Microbiota.Probiotics and antimicrobial proteins · 2026Article
- Lactobacillus reuteri SKLAN202402ZF inhibited by early-life lincomycin exposure alleviate intestinal damage and inflammation sensitivity.Microbiome · 2026Article
- Probiotics Ameliorate Histological Alterations and Prevent Increases in Cytokine and Toxin Levels in Mice Infected with Various Clostridioides difficile Strains.Probiotics and antimicrobial proteins · 2026Article
- Next-Generation Microencapsulation Technologies for Probiotic Protection and Precision Delivery.Microbial biotechnology · 2026Review
- Article
- Role ofFrontiers in pediatrics · 2026Article
- Probiotics as Adjuvants to StandardMicroorganisms · 2025Review
- Bifidobacterium bifidum G9-1 Survives in the Intestinal Environment and Influences the Gut Microbiota Despite the Presence of Antimicrobials.Microbiology and immunology · 2025Article
- Primary care and specialist physicians' prescribing preferences for concurrent probiotic-antibiotic therapy: a multinational clinical practice survey across 13 countries.Frontiers in medicine · 2025Article
- Probiotic use reduces the incidence of antibiotic-associated diarrhea among adult patients: a meta-analysis.Przeglad gastroenterologiczny · 2025Review
- Diagnosing and engineering gut microbiomes.EMBO molecular medicine · 2024Review
- A Comparison of Outcomes from Antibiotic Treatment with and without Probiotics in 897 Patients with Lower Urogenital Tract Infections, Including Cystitis, Urethritis, Prostatitis, and Vulvovaginitis.Medical science monitor basic research · 2024Article
- The effect of fecal microbiota transplantation on antibiotic-associated diarrhea and its impact on gut microbiota.BMC microbiology · 2024Article
- Prebiotics and Probiotics for Gastrointestinal Disorders.Nutrients · 2024Review
- Effect of probiotic yogurt on antibiotic-associated diarrhea among pediatric patients; randomized controlled trial.Journal of education and health promotion · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis meta-analysis aims to combine the latest research evidence to assess the effect of probiotics on preventing antibiotic-associated diarrhea (AAD) in adults.
methodsPubMed, Cochrane Library, EMBASE, and Web of Science were searched for randomized placebo-controlled trials on probiotics preventing AAD. A random or fixed effect model was used to combine the incidence of AAD (primary outcome) and the adverse event rates. The authors performed subgroup analyses to explore the effects of different participants population, probiotics species, and dosage.
resultsThirty-six studies were included with 9312 participants. Probiotics reduced the incidence of AAD by 38% (pooled relative risk, 0.62; 95% confidence interval, 0.51-0.74). The protective effect of probiotics was still significant when grouped by reasons for antibiotics treatment, probiotic duration, probiotic dosage, and time from antibiotic to probiotic. However, there were no statistically significant increased adverse events in the probiotics group (relative risk, 1.00; 95% confidence interval, 0.87-1.14).
conclusionsThis updated meta-analysis suggested that using probiotics as early as possible during antibiotic therapy has a positive and safe effect on preventing AAD in adults. Further studies should focus on the optimal dosage and duration of probiotics to develop a specific recommendation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.