Evidence map›Paper›PMID 33234717›Full record

ArticleDevelopment (Cambridge, England)2021

Ccn2a is an injury-induced matricellular factor that promotes cardiac regeneration in zebrafish.

Debanjan Mukherjee, Ganesh Wagh, Mayssa H Mokalled, Zacharias Kontarakis, Amy L Dickson, Amey Rayrikar, Stefan Günther, Kenneth D Poss, Didier Y R Stainier, Chinmoy Patra

Open access · bronzeAbstract read
In one paragraph

Article in Development (Cambridge, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Tunable gene expression in zebrafish using RiboSCALE.bioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Review
  6. Position-specific methyl substitution on benzo[a]pyrene drives AHR-dependent fin duplication in zebrafish.Toxicological sciences : an official journal of the Society of Toxicology · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Expanding the CRISPR/Cas toolkit: applications in proteomics and theranostics.Frontiers in bioengineering and biotechnology · 2025
    Review
  12. Article
  13. leptin b and its regeneration enhancer illustrate the regenerative features of zebrafish hearts.Developmental dynamics : an official publication of the American Association of Anatomists · 2024
    Article
  14. Loss ofBiomolecules · 2023
    Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Debanjan MukherjeeDepartment of Developmental Biology, Agharkar Research Institute, Pune 411004, India.ORCID 0000-0002-0788-6460
Ganesh WaghDepartment of Developmental Biology, Agharkar Research Institute, Pune 411004, India.
Mayssa H MokalledRegeneration Next, Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.ORCID 0000-0002-3712-351X
Zacharias KontarakisMax Planck Institute for Heart and Lung Research, Department of Developmental Genetics, Bad Nauheim 61231, Germany.
Amy L DicksonRegeneration Next, Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.
Amey RayrikarDepartment of Developmental Biology, Agharkar Research Institute, Pune 411004, India.
Stefan GüntherECCPS Bioinformatics and Deep Sequencing Platform, Max Planck Institute for Heart and Lung Research, Bad Nauheim 61231, Germany.
Kenneth D PossRegeneration Next, Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.
Didier Y R StainierMax Planck Institute for Heart and Lung Research, Department of Developmental Genetics, Bad Nauheim 61231, Germany.ORCID 0000-0002-0382-0026
Chinmoy PatraDepartment of Developmental Biology, Agharkar Research Institute, Pune 411004, India cpatra@aripune.org.ORCID 0000-0003-3997-8607
Agharkar Research Institute · INDuke Medical Center · USMax Planck Institute for Heart and Lung Research · DE

Funding

Regulation of Myocardial Regeneration in ZebrafishR01HL081674 · NHLBI · DUKE UNIVERSITY · PI POSS, KENNETH D · 2005 to 2019
$6.6M
Regulation of the Epicardial Injury Response During Heart Regeneration in ZebrafishR01HL131319 · NHLBI · DUKE UNIVERSITY · PI POSS, KENNETH D · 2016 to 2019
$1.6M
NHLBI NIH HHS R01 HL081674NHLBI NIH HHS R01 HL131319
6 · The paper itself

Abstract

The ability of zebrafish to heal their heart after injury makes them an attractive model for investigating the mechanisms governing the regenerative process. In this study, we show that the gene

Indexed as

RegenerationAnimalsCell NucleusCell ProliferationConnective Tissue Growth FactorCoronary VesselsEndocardiumExtracellular MatrixGene Expression Regulation, DevelopmentalHeartMutationMyocytes, CardiacPhosphorylationProtein TransportSmad ProteinsTransforming Growth Factor beta1ccn2a protein, zebrafishConnective Tissue Growth FactorSmad ProteinsTransforming Growth Factor beta1Zebrafish ProteinsCcn2aCtgfExtracellular matrixHeart regenerationTGFβZebrafish

Identifiers

PMID33234717
PMCPMC7847265
OpenAlexW3108608243

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.