Evidence map›Paper›PMID 33234689›Full record

ArticlemBio2020

Genes Contributing to the Unique Biology and Intrinsic Antibiotic Resistance of Enterococcus faecalis.

Michael S Gilmore, Rauf Salamzade, Elizabeth Selleck, Noelle Bryan, Suelen S Mello, Abigail L Manson, Ashlee M Earl

Open access · goldAbstract read
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
0.5field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
  2. The novel pseudo-compound transposon TnMicrobial genomics · 2026
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  9. Insights into ecology, pathogenesis, and biofilm formation ofMicrobiology and molecular biology reviews : MMBR · 2025
    Review
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  11. Spatial population dynamics of bacterial colonies with social antibiotic resistance.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. PgpP is a broadly conserved phosphatase required for phosphatidylglycerol lipid synthesis.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  13. Review
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  15. Article
  16. Microbiology spectrum · 2024
    Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Michael S GilmoreDepartment of Ophthalmology, Harvard Medical School and Mass Eye and Ear, Boston, Massachusetts, USA michael_gilmore@meei.harvard.edu aearl@broadinstitute.org.
Rauf SalamzadeInfectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Elizabeth SelleckDepartment of Ophthalmology, Harvard Medical School and Mass Eye and Ear, Boston, Massachusetts, USA.
Noelle BryanDepartment of Ophthalmology, Harvard Medical School and Mass Eye and Ear, Boston, Massachusetts, USA.
Suelen S MelloDepartment of Ophthalmology, Harvard Medical School and Mass Eye and Ear, Boston, Massachusetts, USA.
Abigail L MansonInfectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.ORCID 0000-0002-3800-0714
Ashlee M EarlInfectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA michael_gilmore@meei.harvard.edu aearl@broadinstitute.org.
Broad Institute · USMassachusetts Eye and Ear Infirmary · US

Funding

Viral Genomics: evolution, spread, and host interactionsU19AI110818 · NIAID · BROAD INSTITUTE, INC. · PI NEAFSEY, DANIEL E · 2014 to 2024
$66.5M
Technical Mother Machine CoreP01AI083214 · NIAID · SCHEPENS EYE RESEARCH INSTITUTE · PI David C Hooper · 2009 to 2026
$39.4M
New understanding of LTA as a determinant of daptomycin susceptibility in VRE E. faeciumR21AI146715 · NIAID · MASSACHUSETTS EYE AND EAR INFIRMARY · PI GILMORE, MICHAEL S · 2019 to 2020
$468k
NIAID NIH HHS HHSN272200900018CNIAID NIH HHS P01 AI083214NIAID NIH HHS R21 AI146715NIAID NIH HHS U19 AI110818
6 · The paper itself

Abstract

The enterococci, which are among the leading causes of multidrug-resistant (MDR) hospital infection, are notable for their environmental ruggedness, which extends to intrinsic antibiotic resistance. To identify genes that confer this unique property, we used Tn-seq to comprehensively explore the genome of MDR

Indexed as

Drug Resistance, MicrobialAnti-Bacterial AgentsBacterial ProteinsEnterococcus faecalisGene Expression Regulation, BacterialGene LibraryGene Regulatory NetworksGenetic FitnessGenome, BacterialGenomicsGram-Positive Bacterial InfectionsHumansStress, PhysiologicalAnti-Bacterial AgentsBacterial Proteinsantibiotic resistancecell wallEnterococcus faecalisevolutionary biologygenomesmetabolismtoxin/antitoxin systemstwo-component signal

Identifiers

PMID33234689
PMCPMC7701990
OpenAlexW3110063350

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.