Evidence map›Paper›PMID 33234631›Full record

ArticleBMJ open2020

Impact of allergic rhinitis on the day-to-day lives of children: insights from an Australian cross-sectional study.

Sinthia Bosnic-Anticevich, Peter Smith, Michael Abramson, Charlotte Mary Hespe, Menai Johnson, Rodney Stosic, David B Price

Open access · goldAbstract read
In one paragraph

Article in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 26 citations in OpenAlex.

  1. Allergic rhinitis activity and efficacy of 300 IR house dust mite sublingual immunotherapy tablet in pediatrics.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026
    Trial
  2. Trial
  3. Prevalence and Sociodemographic Variation of Allergic Diseases in Australia: Findings From the Australian National Health Survey.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 3 countries.

Sinthia Bosnic-AnticevichDepartment Lead, Quality Use of Medicines Group, Woolcock Institute of Medical Research, University of Sydney, Sydney Local Health District, Sydney, New South Wales, Australia Sinthia.Bosnic-Anticevich@sydney.edu.au.ORCID 0000-0001-5077-8329
Peter SmithProfessor of Clinical Medicine, Griffith University, Southport, Queensland, Australia.
Michael AbramsonProfessor of Clinical Epidemiology, School of Public Health and Preventive Medicine, Monash University and Honorary Medical Officer in Respiratory Medicine, Alfred Hospital, Melbourne, Victoria, Australia.
Charlotte Mary HespeGeneral Practitioner & Head of Primary Care Research, University of Notre Dame, Australia (Sydney School of Medicine), Sydney & Director Asthma Foundation, Sydney, New South Wales, Australia.
Menai JohnsonHead of Central Medical Operations, Real World Clinical Evidence, Sanofi Australia/New Zealand, Sydney, New South Wales, Australia.
Rodney StosicFormerly Head of Medical Affairs, Sanofi Consumer Healthcare, Sydney, New South Wales, Australia.
David B PriceManaging Director, Observational and Pragmatic Research Institute, Singapore.ORCID 0000-0002-9728-9992
Sanofi (Australia) · AUGriffith University · AUMonash University · AUThe University of Notre Dame Australia · AUThe University of Sydney · AUUniversity of Aberdeen · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY DESIGN AND

objectiveCross-sectional, observational survey to describe the impact of allergic rhinitis (AR) on Australian children (2 to 15 years).

methodsParticipants (n=1541), parents of children aged 2 to 15 years, provided information on behalf of themselves and one eligible child in their household using a custom-built online questionnaire. Children were allocated to case (AR) or control (No AR) analysis groups based on a validated screening questionnaire. STATISTICAL

methodsThe study sample was stratified on age: primary analysis population (6 to 15 years, n=1111; AR=797, No AR=314); exploratory population (2 to 5 years). The primary endpoint, parent-perceived burden, was quantified using a validated measure of health status and analysed via comparison of means.

resultsThe majority of AR cases were treated (730/797; 90.3%) and classified as having moderate-severe, intermittent AR (549/797; 68.9%). Half reported adequate symptom control in the prior 2 weeks (389/797; 48.8%; OR=4.04; 95% CI (CI) 2.24 to 7.31). Having AR was associated with worse overall health status (7.4 vs 8.4, mean difference (least squares mean difference (LSMD))=-0.99; 95% CI -1.18 to -0.79), fewer days being happy (22.2 vs 25.9, LSMD=-3.68; 95% CI -4.82 to -2.54) and more days of poor physical (2.82 vs 0.78, LSMD=2.04; 95% CI 1.61 to 2.47) and emotional (2.14 vs 0.67, LSMD=1.47; 95% CI 1.02 to -1.92) health compared with not having AR. All of these outcomes were significantly (p<0.05) worse in children who reported inadequate symptom control. Having AR negatively impacted on schoolwork, sleep and other activities, and increased the likelihood of having comorbidities.

conclusionThe parent-perceived burden of AR in Australian children is high and it impacts many areas of day-to-day living. Inadequate symptom control is a key driver of the extent of this impact. Opportunities to optimise the management of AR in children include the adoption of self-assessment tools to gauge and monitor adequacy of symptom control.

Indexed as

Rhinitis, AllergicAdolescentAustraliaChildChild, PreschoolComorbidityCross-Sectional StudiesHumansQuality of LifeSurveys and Questionnairesallergypaediatric thoracic medicinequality in health care

Identifiers

PMID33234631
PMCPMC7689068
OpenAlexW3092042124

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.