Evidence map›Paper›PMID 33234629›Full record

ArticleBMJ open2020

Patterns of multimorbidity and their effects on adverse outcomes in rheumatoid arthritis: a study of 5658 UK Biobank participants.

Ross McQueenie, Barbara I Nicholl, Bhautesh D Jani, Jordan Canning, Sara Macdonald, Colin McCowan, Joanne Neary, Susan Browne, Frances S Mair, Stefan Siebert

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

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  11. Osteoporosis in Rheumatology.Indian journal of orthopaedics · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Ross McQueenieGeneral Practice and Primary Care, Institute of Health and Wellbeing, MVLS, University of Glasgow, Glasgow, UK.ORCID 0000-0002-0070-6607
Barbara I NichollGeneral Practice and Primary Care, Institute of Health and Wellbeing, MVLS, University of Glasgow, Glasgow, UK.
Bhautesh D JaniGeneral Practice and Primary Care, Institute of Health and Wellbeing, MVLS, University of Glasgow, Glasgow, UK.
Jordan CanningGeneral Practice and Primary Care, Institute of Health and Wellbeing, MVLS, University of Glasgow, Glasgow, UK.
Sara MacdonaldGeneral Practice and Primary Care, Institute of Health and Wellbeing, MVLS, University of Glasgow, Glasgow, UK.
Colin McCowanSchool of Medicine, University of St. Andrews, Saint Andrews, UK.
Joanne NearyGeneral Practice and Primary Care, Institute of Health and Wellbeing, MVLS, University of Glasgow, Glasgow, UK.
Susan BrowneGeneral Practice and Primary Care, Institute of Health and Wellbeing, MVLS, University of Glasgow, Glasgow, UK.
Frances S Mair *General Practice and Primary Care, Institute of Health and Wellbeing, MVLS, University of Glasgow, Glasgow, UK.
Stefan Siebert *Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK Stefan.Siebert@glasgow.ac.uk.ORCID 0000-0002-1802-7311
University of Glasgow · GBNational Health Service Scotland · GBUniversity of St Andrews · GB

Funding

Medical Research Council MC_PC_17228Medical Research Council MC_QA137853Versus Arthritis 21970
6 · The paper itself

Abstract

objectiveTo investigate how the type and number of long-term conditions (LTCs) impact on all-cause mortality and major adverse cardiovascular events (MACE) in people with rheumatoid arthritis (RA).

designPopulation-based longitudinal cohort study.

settingUK Biobank.

participantsUK Biobank participants (n=502 533) aged between 37 and 73 years old. PRIMARY OUTCOME MEASURES: Primary outcome measures were risk of all-cause mortality and MACE.

methodsWe examined the relationship between LTC count and individual comorbid LTCs (n=42) on adverse clinical outcomes in participants with self-reported RA (n=5658). Risk of all-cause mortality and MACE were compared using Cox's proportional hazard models adjusted for lifestyle factors (smoking, alcohol intake, physical activity), demographic factors (sex, age, socioeconomic status) and rheumatoid factor.

results75.7% of participants with RA had multimorbidity and these individuals were at increased risk of all-cause mortality and MACE. RA and

conclusionThose with RA and other LTCs, particularly comorbid osteoporosis, are at increased risk of adverse outcomes, although the role of corticosteroids could not be evaluated in this study. These results are clinically relevant for the monitoring and management of RA across the healthcare system, and future clinical guidelines for RA should acknowledge the importance of multimorbidity.

Indexed as

Arthritis, RheumatoidMultimorbidityAdultAgedBiological Specimen BanksHumansLongitudinal StudiesMiddle AgedRisk FactorsUnited Kingdomcardiologyepidemiologyrheumatology

Identifiers

PMID33234629
PMCPMC7684828
OpenAlexW3099542260

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.