Evidence map›Paper›PMID 33234490›Full record

ArticleClinical lung cancer2021

Deep and Durable Response to Nivolumab and Temozolomide in Small-Cell Lung Cancer Associated With an Early Decrease in Myeloid-Derived Suppressor Cells.

Dwight H Owen, Brooke Benner, Carly Pilcher, Logan Good, Himanshu Savardekar, Ruthann Norman, Christian Ghattas, Manisha Shah, Bhavana Konda, Claire F Verschraegen and 4 more

Open access · greenAbstract readCase Reports
In one paragraph

Article in Clinical lung cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Current and future therapies for small cell lung carcinoma.Journal of hematology & oncology · 2025
    Review
  5. Review
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Dwight H OwenDivision of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, James Cancer Hospital and Solove Research Institute, Columbus, OH. Electronic address: Dwight.Owen@osumc.edu.
Brooke BennerThe Ohio State University Comprehensive Cancer Center, James Cancer Hospital and Solove Research Institute, Columbus, OH.
Carly PilcherClinical Trials Office, The Ohio State University Comprehensive Cancer Center, James Cancer Hospital and Solove Research Institute, Columbus, OH.
Logan GoodThe Ohio State University Comprehensive Cancer Center, James Cancer Hospital and Solove Research Institute, Columbus, OH.
Himanshu SavardekarThe Ohio State University Comprehensive Cancer Center, James Cancer Hospital and Solove Research Institute, Columbus, OH.
Ruthann NormanThe Ohio State University Comprehensive Cancer Center, James Cancer Hospital and Solove Research Institute, Columbus, OH.
Christian GhattasDivision of Pulmonary Medicine, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH.
Manisha ShahDivision of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, James Cancer Hospital and Solove Research Institute, Columbus, OH.
Bhavana KondaDivision of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, James Cancer Hospital and Solove Research Institute, Columbus, OH.
Claire F VerschraegenDivision of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, James Cancer Hospital and Solove Research Institute, Columbus, OH.
Robert WesolowskiDivision of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, James Cancer Hospital and Solove Research Institute, Columbus, OH.
Gregory K BehbehaniDivision of Hematology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, James Cancer Hospital and Solove Research Institute, Columbus, OH.
William E CarsonDivision of Surgical Oncology, Department of Surgery, The Ohio State University Comprehensive Cancer Center, James Cancer Hospital and Solove Research Institute, Columbus, OH.
Gregory A OttersonDivision of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, James Cancer Hospital and Solove Research Institute, Columbus, OH.
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute · USThe Ohio State University Wexner Medical Center · US

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Jennifer A. Woyach · 1985 to 2026
$132.3M
Translational Training Grant in Experimental TherapeuticsK12CA133250 · NCI · OHIO STATE UNIVERSITY · PI WILLIAM E. CARSON, Rosa Lapalombella · 2008 to 2026
$15.0M
NCI NIH HHS K12 CA133250NCI NIH HHS P30 CA016058
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AgedAntineoplastic Combined Chemotherapy ProtocolsHumansLung NeoplasmsMaleMyeloid-Derived Suppressor CellsNivolumabSmall Cell Lung CarcinomaTemozolomideTreatment OutcomeNivolumabTemozolomideBiomarkerChemotherapyImmune checkpoint inhibitorImmunomodulationImmunotherapy

Identifiers

PMID33234490
PMCPMC8088448
OpenAlexW3096564526

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.