ArticleJournal of pharmaceutical and biomedical analysis2021
Composition analysis of falsified chloroquine phosphate samples seized during the COVID-19 pandemic.
Article in Journal of pharmaceutical and biomedical analysis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Suspected poor-quality medicines in Kenya: a retrospective descriptive study of medicine quality-related complaints reports in Kenya's pharmacovigilance database.BMC public health · 2024Article
- Quality of Essential Medicines from Different Sources in Enugu and Anambra, Nigeria.The American journal of tropical medicine and hygiene · 2024Article
- Corruption risks in health procurement during the COVID-19 pandemic and anti-corruption, transparency and accountability (ACTA) mechanisms to reduce these risks: a rapid review.Globalization and health · 2023Review
- The response to substandard and falsified medical products in francophone sub-Saharan African countries: weaknesses and opportunities.Journal of pharmaceutical policy and practice · 2023Article
- Detection of Substandard and Falsified Antibiotics Sold in the Democratic Republic of the Congo Using Validated HPLC and UV-Visible Spectrophotometric Methods.The American journal of tropical medicine and hygiene · 2023Article
- Electrochemical Determination of Chloroquine Phosphate in Real Samples Using a Diresorcinate-1,10-phenanthrolinecobalt(II)-Modified Glassy Carbon Electrode.ChemistryOpen · 2023Article
- Prevalence of Poor Quality Ciprofloxacin and Metronidazole Tablets in Three Cities in Cameroon.The American journal of tropical medicine and hygiene · 2023Article
- Usefulness of medicine screening tools in the frame of pharmaceutical post-marketing surveillance.PloS one · 2023Article
- Trends in counterfeit drugs and pharmaceuticals before and during COVID-19 pandemic.Forensic science international · 2022Review
- Review
- Analysis of pharmacovigilance databases for spontaneous reports of adverse drug reactions related to substandard and falsified medical products: A descriptive study.Frontiers in pharmacology · 2022Article
- Cuttlefish bone powder as an efficient solid-phase extraction sorbent of anti-SARS-CoV-2 drugs in environmental water.Chemicke zvesti · 2022Article
- Investigation of potential substandard dry powder inhalers on EU and North African markets - evaluation of the delivered and fine particle doses.Journal of drug assessment · 2022Article
- Confocal Raman Spectroscopic Imaging for Evaluation of Distribution of Nano-Formulated Hydrophobic Active Cosmetic Ingredients in Hydrophilic Films.Molecules (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The proliferation of falsified medicines can cause serious public health issues, particularly in the context of a global pandemic such as the actual COVID-19 pandemic. Our study involved eight chloroquine phosphate medicines seized in Cameroon, Democratic Republic of Congo and Niger during March and May 2020. These suspect samples were first analyzed in a screening phase using field tools such as handheld Raman spectroscopy (TruScan) and then in a confirmation phase using laboratory tools such as hyperspectral Raman imaging and High Performance Liquid Chromatography (HPLC). The results confirmed the falsified nature of the samples, highlighting the presence of metronidazole at low dose in four samples (16.6, 15.2, 15.2 and 14.5 mg/tab), too low levels of chloroquine in two samples (2.4 and 20.2 mg/tab), and substitution of chloroquine phosphate by paracetamol in one sample (255.7 mg/tab). The results also confirmed that four samples had been adulterated with paracetamol in trace amounts and two of them presented traces of chloramphenicol.
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