Observational studyBMC cardiovascular disorders2020
Association between serum lactate levels and mortality in patients with cardiogenic shock receiving mechanical circulatory support: a multicenter retrospective cohort study.
Observational study in BMC cardiovascular disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Effects and safety of extracorporeal membrane oxygenation in the treatment of patients with ST-segment elevation myocardial infarction and cardiogenic shock: A systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2022Pooled it
- Microcirculation and Cerebrovascular Autoregulation in Patients With Mechanical Circulatory Support Devices.Journal of stroke · 2026Review
- Development and internal validation of an interpretable machine learning model to predict coagulopathy following extracorporeal membrane oxygenation: a retrospective multicenter study.Scandinavian journal of trauma, resuscitation and emergency medicine · 2026Article
- Effects of Initial Lactate Levels and 24-h Lactate Clearance on Mortality in Post-Cardiac Arrest Patients: Insights from the Multicenter TIMECARD Registry.International journal of medical sciences · 2026Article
- Clinical Features and Mortality of ICU Patients with Thyroid Storm Receiving Extracorporeal Membrane Oxygenation: A Single-Center Experience in Taiwan.Acta Cardiologica Sinica · 2025Article
- SCAI Door to Lactate Clearance (SCAI DLC) Cardiogenic Shock Initiative: Definition, Hypothesis, and Call to Action.Journal of the Society for Cardiovascular Angiography & Interventions · 2025Article
- Macrovascular Hemodynamics and Peripheral Perfusion in Cardiogenic Shock: Exploring Current Targets and Future Directions.JACC. Advances · 2025Review
- Transcatheter Aortic Valve Implantation in Cardiogenic Shock: Current Evidence, Clinical Challenges, and Future Directions.Journal of clinical medicine · 2025Review
- Current and novel biomarkers in cardiogenic shock.European journal of heart failure · 2025Review
- Prognostic accuracy of oxygen debt for mortality in patients undergoing venoarterial extracorporeal membrane oxygenation therapy: a retrospective cohort study.Frontiers in medicine · 2025Article
- Biomarkers in cardiogenic shock: old pals, new friends.Annals of intensive care · 2024Review
- Association between measures of resuscitation in the critical care resuscitation unit and in-hospital mortality among patients with sepsis.Journal of the American College of Emergency Physicians open · 2024Article
- The glycemic gap as a prognostic indicator in cardiogenic shock: a retrospective cohort study.BMC cardiovascular disorders · 2024Observational
- Normalized lactate load as an independent prognostic indicator in patients with cardiogenic shock.BMC cardiovascular disorders · 2024Article
- Lactate Profile Assessment-A Good Predictor of Prognosis in Patients with COVID-19 and Septic Shock Requiring Continuous Renal Therapy.Clinics and practice · 2024Article
- Review
- Mechanical circulatory support with ECMELLA approach in severe cardiogenic shock patients-state of the art.Journal of thoracic disease · 2023Article
- Understanding lactate and its clearance during extracorporeal membrane oxygenation for supporting refractory cardiogenic shock patients.BMC cardiovascular disorders · 2023Article
- Capillary Refill Time and Serum Lactate as Predictors of Mortality and Postoperative Extracorporeal Membrane Oxygenation Requirement in Congenital Heart Surgery.Children (Basel, Switzerland) · 2023Article
- Reply to the letter "Understanding lactate and its clearance during extracorporeal membrane oxygenation for supporting refractory cardiogenic shock patients".BMC cardiovascular disorders · 2023Article
Corrections and comments
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Authors and funding
16 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo evaluate the prognostic value of peak serum lactate and lactate clearance at several time points in cardiogenic shock treated with temporary mechanical circulatory support (MCS) using veno-arterial extracorporeal membrane oxygenation (VA-ECMO) or Impella CP
methodsSerum lactate and clearance were measured before MCS and at 1 h, 6 h, 12 h, and 24 h post-MCS in 43 patients at four tertiary-care centers in Southern Brazil. Prognostic value was assessed by univariable and multivariable analysis and receiver operating characteristic (ROC) curves for 30-day mortality.
resultsVA-ECMO was the most common MCS modality (58%). Serum lactate levels at all time points and lactate clearance after 6 h were associated with mortality on unadjusted and adjusted analyses. Lactate levels were higher in non-survivors at 6 h, 12 h, and 24 h after MCS. Serum lactate > 1.55 mmol/L at 24 h was the best single prognostic marker of 30-day mortality [area under the ROC curve = 0.81 (0.67-0.94); positive predictive value = 86%). Failure to improve serum lactate after 24 h was associated with 100% mortality.
conclusionsSerum lactate was an important prognostic biomarker in cardiogenic shock treated with temporary MCS. Serum lactate and lactate clearance at 24 h were the strongest independent predictors of short-term survival.
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