ArticleMolecules (Basel, Switzerland)2020
Ultrasound-Assisted Deep Eutectic Solvent Extraction of Anthocyanins from Blueberry Wine Residues: Optimization, Identification, and HepG2 Antitumor Activity.
Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Ultrasound-Assisted DES Extraction of Black Rice Anthocyanins: Optimization, Characterization, and Bioactivity.Journal of food science · 2026Article
- Natural Bioactive Compounds: Integrated Analytical and Biological Approaches for the Special Issue "Analysis and Biological Evaluation of Bioactive Compounds from Natural Sources".Molecules (Basel, Switzerland) · 2026Article
- Sustainable valorization of grape pomace peels using NADES: a focus on selective recovery of anthocyanins and flavonols and bioactivity.Analytical and bioanalytical chemistry · 2026Article
- Technological Innovations and Circular Economy in the Valorization of Agri-Food By-Products: Advances, Challenges and Perspectives.Foods (Basel, Switzerland) · 2025Review
- Opportunities and challenges of foodborne polyphenols applied to anti-aging health foods.Food science and biotechnology · 2024Review
- Green Solvents for Extraction of Natural Food Colorants from Plants: Selectivity and Stability Issues.Foods (Basel, Switzerland) · 2024Review
- Green Extraction of Polyphenols via Deep Eutectic Solvents and Assisted Technologies from Agri-Food By-Products.Molecules (Basel, Switzerland) · 2023Review
- Research Progress on Absorption, Metabolism, and Biological Activities of Anthocyanins in Berries: A Review.Antioxidants (Basel, Switzerland) · 2022Review
- Yellow pigment from gardenia fruit: structural identification and evaluation of cytotoxic activity in HepG2 cells by induction of apoptosis.Food science and biotechnology · 2022Article
- Ultrasound-Assisted Deep Eutectic Solvents Extraction of Polysaccharides FromFrontiers in nutrition · 2022Article
- Tea polyphenols alleviate hydrogen peroxide-induced oxidative stress damage through the Mst/Nrf2 axis and the Keap1/Nrf2/HO-1 pathway in murine RAW264.7 cells.Experimental and therapeutic medicine · 2021Article
- Optimization the extraction of anthocyanins from blueberry residue by dual-aqueous phase method and cell damage protection study.Food science and biotechnology · 2021Article
- Extraction and Stabilization of Betalains from Beetroot (Molecules (Basel, Switzerland) · 2021Article
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5 authors.
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Abstract
Blueberry wine residues produced during the wine-brewing process contain abundant anthocyanins and other bioactive compounds. To extract anthocyanins from blueberry wine residues more efficiently, a novel procedure of ultrasound-assisted deep eutectic solvent extraction (UADESE) was proposed in this work. The extraction process was optimized by response surface methodology coupled with genetic algorithm. The optimum extraction parameters to achieve the highest yield of anthocyanins (9.32 ± 0.08 mg/g) from blueberry wine residues by UADESE were obtained at water content of 29%, ultrasonic power of 380 W, extraction temperature of 55 °C, and extraction time of 40 min. The AB-8 macroporous resin combined with Sephadex LH-20 techniques was used to purify the crude extract (CE) obtained under optimum extraction conditions and analyze the anthocyanins composition by HPLC-ESI-MS/MS. The cyanidin-3-rutinoside with purity of 92.81% was obtained. The HepG2 antitumor activity of CE was better than that of the purified anthocyanins component. Moreover, CE could increase the intracellular reactive oxygen species levels and the apoptosis, and arrest HepG2 cells in the S phases. These findings provided an effective and feasible method for anthocyanins extraction, and reduced the environmental burden of this waste.
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