Evidence map›Paper›PMID 33233711›Full record

ArticleMolecules (Basel, Switzerland)2020

On the Different Mode of Action of Au(I)/Ag(I)-NHC Bis-Anthracenyl Complexes Towards Selected Target Biomolecules.

Francesca Binacchi, Federica Guarra, Damiano Cirri, Tiziano Marzo, Alessandro Pratesi, Luigi Messori, Chiara Gabbiani, Tarita Biver

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. A CD Study of a Structure-Based Selection ofMolecules (Basel, Switzerland) · 2024
    Article
  3. Article
  4. Reaction Behavior of [1,3-Diethyl-4,5-diphenyl-1Journal of medicinal chemistry · 2023
    Article
  5. Review
  6. Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Francesca BinacchiDepartment of Chemistry and Industrial Chemistry, University of Pisa, Via G. Moruzzi 13, 56124 Pisa, Italy.
Federica GuarraDepartment of Chemistry and Industrial Chemistry, University of Pisa, Via G. Moruzzi 13, 56124 Pisa, Italy.
Damiano CirriDepartment of Chemistry and Industrial Chemistry, University of Pisa, Via G. Moruzzi 13, 56124 Pisa, Italy.
Tiziano MarzoDepartment of Pharmacy, University of Pisa, Via Bonanno Pisano 6, 56126 Pisa, Italy.ORCID 0000-0002-2567-3637
Alessandro PratesiDepartment of Chemistry and Industrial Chemistry, University of Pisa, Via G. Moruzzi 13, 56124 Pisa, Italy.ORCID 0000-0002-9553-9943
Luigi MessoriLaboratory of Metals in Medicine (MetMed), Department of Chemistry "Ugo Schiff", University of Florence, Via della Lastruccia 3-13, 50019 Sesto Fiorentino, Italy.ORCID 0000-0002-9490-8014
Chiara GabbianiDepartment of Chemistry and Industrial Chemistry, University of Pisa, Via G. Moruzzi 13, 56124 Pisa, Italy.
Tarita BiverDepartment of Chemistry and Industrial Chemistry, University of Pisa, Via G. Moruzzi 13, 56124 Pisa, Italy.ORCID 0000-0001-8512-8422

Funding

Associazione Italiana per la Ricerca sul Cancro (AIRC) 23852Associazione Italiana per la Ricerca sul Cancro (AIRC) Multi-user Equipment Program 2016, Ref. code 19650Beneficentia Stiftung, Vaduz BEN2019/48Beneficentia Stiftung, Vaduz BEN2020/34Fondazione Cassa Risparmio Firenze Multi-user Equipment Program 2016, Ref. code 19650Junta de Castilla y León BU305P18"la Caixa" Foundation LCF/PR/PR12/11070003Ministerio de Ciencia, Innovación y Universidades RTI2018-102040-B-100University of Pisa PRA_2020_39University of Pisa PRA_2020_58University of Pisa Rating Ateneo 2019-2020
6 · The paper itself

Abstract

Gold and silver N-heterocyclic carbenes (NHCs) are emerging for therapeutic applications. Multiple techniques are here used to unveil the mechanistic details of the binding to different biosubstrates of bis(1-(anthracen-9-ylmethyl)-3-ethylimidazol-2-ylidene) silver chloride [Ag(EIA)

Indexed as

AlgorithmsDNAGoldHeterocyclic CompoundsMacromolecular SubstancesMethaneModels, TheoreticalMolecular StructureNucleic Acid DenaturationRNASerum Albumin, BovineSilverSpectrum AnalysisStructure-Activity RelationshipThermodynamicscarbeneDNAGoldHeterocyclic CompoundsMacromolecular SubstancesMethaneRNASerum Albumin, BovineSilvergold carbenemode of actionnucleic acidsprotein metalationquadruplexessilver carbenetarget selectivity

Identifiers

PMID33233711
PMCPMC7699860

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.