Evidence map›Paper›PMID 33233698›Full record

ArticleBrain sciences2020

Classification of Primary Cerebral Lymphoma and Glioblastoma Featuring Dynamic Susceptibility Contrast and Apparent Diffusion Coefficient.

Felix Eisenhut, Manuel A Schmidt, Florian Putz, Sebastian Lettmaier, Kilian Fröhlich, Soheil Arinrad, Roland Coras, Hannes Luecking, Stefan Lang, Rainer Fietkau and 1 more

Open access · goldAbstract read
In one paragraph

Article in Brain sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
1.1field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Evaluation of [Journal of clinical medicine · 2025
    Article
  4. Article
  5. Article
  6. Review
  7. Differentiating primary central nervous system lymphoma from glioblastoma by time-dependent diffusion using oscillating gradient.Cancer imaging : the official publication of the International Cancer Imaging Society · 2023
    Article
  8. Article
  9. Differentiating brain metastasis from glioblastoma by time-dependent diffusion MRI.Cancer imaging : the official publication of the International Cancer Imaging Society · 2023
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Time-dependent MR diffusion analysis of functioning and nonfunctioning pituitary adenomas/pituitary neuroendocrine tumors.Journal of neuroimaging : official journal of the American Society of Neuroimaging
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Felix EisenhutDepartment of Neuroradiology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany.
Manuel A SchmidtDepartment of Neuroradiology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany.ORCID 0000-0002-8560-2582
Florian PutzDepartment of Radiation Oncology, University of Erlangen-Nuremberg, Universitaetsstrasse 27, 91054 Erlangen, Germany.ORCID 0000-0003-3966-2872
Sebastian LettmaierDepartment of Radiation Oncology, University of Erlangen-Nuremberg, Universitaetsstrasse 27, 91054 Erlangen, Germany.
Kilian FröhlichDepartment of Neurology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany.ORCID 0000-0002-4908-4044
Soheil ArinradDepartment of Neurosurgery, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany.
Roland CorasDepartment of Neuropathology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany.
Hannes LueckingDepartment of Neuroradiology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany.
Stefan LangDepartment of Neuroradiology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany.
Rainer FietkauDepartment of Radiation Oncology, University of Erlangen-Nuremberg, Universitaetsstrasse 27, 91054 Erlangen, Germany.
Arnd DoerflerDepartment of Neuroradiology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany.
Friedrich-Alexander-Universität Erlangen-Nürnberg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to differentiate primary central nervous system lymphoma (PCNSL) and glioblastoma (GBM) via multimodal MRI featuring radiomic analysis. MRI data sets of patients with histological proven PCNSL and GBM were analyzed retrospectively. Diffusion-weighted imaging (DWI) and dynamic susceptibility contrast (DSC) perfusion imaging were evaluated to differentiate contrast enhancing intracerebral lesions. Selective (contrast enhanced tumor area with the highest mean cerebral blood volume (CBV) value) and unselective (contouring whole contrast enhanced lesion) Apparent diffusion coefficient (ADC) measurement was performed. By multivariate logistic regression, a multiparametric model was compiled and tested for its diagnostic strength. A total of 74 patients were included in our study. Selective and unselective mean and maximum ADC values, mean and maximum CBV and ratio

Indexed as

ADCDSCglioblastomaMRImultimodalprimary central nervous system lymphoma

Identifiers

PMID33233698
PMCPMC7699775
OpenAlexW3103036177

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.