ArticlePharmaceutics2020
Optimal Design of THEDES Based on Perillyl Alcohol and Ibuprofen.
Article in Pharmaceutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Advancements in Therapeutic Deep Eutectic Solvents as Multifunctional Transdermal Delivery Systems.Pharmaceutics · 2026Review
- Capric Acid-Based Therapeutic Deep Eutectic Systems: A Focused Review Within the Framework of Deep Eutectic Solvents.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Exploring Ibuprofen-Menthol Eutectic Systems: Physicochemical Properties and Cytotoxicity for Pharmaceutical Applications.Pharmaceutics · 2025Article
- Enhanced Extraction and Separation with HPLC-DAD of Phenolic and Flavonoid Antioxidants fromAntioxidants (Basel, Switzerland) · 2025Article
- Exploring Deep Eutectic Solvents as Pharmaceutical Excipients: Enhancing the Solubility of Ibuprofen and Mefenamic Acid.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Pharmaceutical applications of therapeutic deep eutectic systems (THEDES) in maximising drug delivery.Heliyon · 2024Review
- Predicting the formation of NADES using a transformer-based model.Scientific reports · 2024Article
- Hydrophobic DES Based on Menthol and Natural Organic Acids for Use in Antifouling Marine Coatings.ACS sustainable chemistry & engineering · 2023Article
- Hydrocinnamic Acid and Perillyl Alcohol Potentiate the Action of Antibiotics againstAntibiotics (Basel, Switzerland) · 2023Article
- Review
- Deep Eutectic Systems as Novel Vehicles for Assisting Drug Transdermal Delivery.Pharmaceutics · 2022Review
- Therapeutic Deep Eutectic Systems towards the Treatment of Tuberculosis and Colorectal Cancer: Opportunities and Challenges.Molecules (Basel, Switzerland) · 2021Review
- Therapeutic Liquid Formulations Based on Low Transition Temperature Mixtures for the Incorporation of Anti-Inflammatory Drugs.Pharmaceutics · 2021Article
- Selected Monocyclic Monoterpenes and Their Derivatives as Effective Anticancer Therapeutic Agents.International journal of molecular sciences · 2021Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Therapeutic deep eutectic systems (THEDES) have dramatically expanded their popularity in the pharmaceutical field due to their ability to increase active pharmaceutical ingredients (APIs) bioavailability. However, their biological performance has not yet been carefully scrutinized. Herein, THEDES based on the binary mixture of perillyl alcohol (POH) and ibuprofen (IBU) were prepared using different molar ratios. Our comprehensive strategy includes the characterization of their thermal and structural behavior to identify the molar ratios that successfully form deep eutectic systems. The in vitro solubility of the different systems prepared has demonstrated that, unlike other reported examples, the presence of the terpene did not affect the solubility of the anti-inflammatory agent in a physiological simulated media. The biological performance of the systems was studied in terms of their antimicrobial activity against a wide panel of microorganisms. The examined THEDES showed relevant antimicrobial activity against all tested microbial strains, with the exception of
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Registered trials
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