Evidence map›Paper›PMID 33233644›Full record

ArticleInternational journal of molecular sciences2020

Genetic Background Underlying 5-HT

Elena M Kondaurova, Alexander Ya Rodnyy, Tatiana V Ilchibaeva, Anton S Tsybko, Dmitry V Eremin, Yegor V Antonov, Nina K Popova, Vladimir S Naumenko

Open access · goldAbstract read

PubMed Full text at PMC Publisher

In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it

0cells of the map it votes in

7citing papers in PubMed

1.6field-weighted citation impact, top 18% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

Systemic Interplay of BDNF and Serotonin Pathways Defines Behavioral and Molecular Responses to Midbrain 5-HT7 Overexpression and Chronic Ethanol Consumption.Biomolecules · 2026
Article
Acipimox as a potential antioxidant and neuromodulator mitigates high fat diet induced cognitive dysfunction.Scientific reports · 2025
Article
Cefaclor causes vagus nerve-mediated depression-like symptoms with gut dysbiosis in mice.Scientific reports · 2023
Article
The Implication of 5-HT Receptor Family Members in Aggression, Depression and Suicide: Similarity and Difference.International journal of molecular sciences · 2022
Review
Role of 5-HT1A-mediated upregulation of brain indoleamine 2,3 dioxygenase 1 in the reduced antidepressant and antihyperalgesic effects of fluoxetine during maintenance treatment.Frontiers in pharmacology · 2022
Article
Effect of Central Administration of Brain-Derived Neurotrophic Factor (BDNF) on Behavior and Brain Monoamine Metabolism in New Recombinant Mouse Lines Differing by 5-HTInternational journal of molecular sciences · 2021
Article
Constitutive Serotonin Tone Modulates Molecular and Behavioral Response to Chronic Fluoxetine Treatment: A Study on Genetic Rat Model.Frontiers in psychiatry · 2021
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Elena M KondaurovaDepartment of Behavioral Neurogenomics, Institute of Cytology and Genetics, Siberian Division, Russian Academy of Sciences, Novosibirsk 630090, Russia.

Alexander Ya RodnyyDepartment of Behavioral Neurogenomics, Institute of Cytology and Genetics, Siberian Division, Russian Academy of Sciences, Novosibirsk 630090, Russia.

Tatiana V IlchibaevaDepartment of Behavioral Neurogenomics, Institute of Cytology and Genetics, Siberian Division, Russian Academy of Sciences, Novosibirsk 630090, Russia.

Anton S TsybkoDepartment of Behavioral Neurogenomics, Institute of Cytology and Genetics, Siberian Division, Russian Academy of Sciences, Novosibirsk 630090, Russia.

Dmitry V EreminDepartment of Behavioral Neurogenomics, Institute of Cytology and Genetics, Siberian Division, Russian Academy of Sciences, Novosibirsk 630090, Russia.

Yegor V AntonovDepartment of Behavioral Neurogenomics, Institute of Cytology and Genetics, Siberian Division, Russian Academy of Sciences, Novosibirsk 630090, Russia.

Nina K PopovaDepartment of Behavioral Neurogenomics, Institute of Cytology and Genetics, Siberian Division, Russian Academy of Sciences, Novosibirsk 630090, Russia.

Vladimir S NaumenkoDepartment of Behavioral Neurogenomics, Institute of Cytology and Genetics, Siberian Division, Russian Academy of Sciences, Novosibirsk 630090, Russia.

Institute of Cytology and Genetics · RU

Funding

Russian Science Foundation 19-15-00027

6 · The paper itself

Abstract

The influence of genetic background on sensitivity to drugs represents a topical problem of personalized medicine. Here, we investigated the effect of chronic (20 mg/kg, 14 days, i.p.) antidepressant fluoxetine treatment on recombinant B6-M76C mice, differed from control B6-M76B mice by CBA-derived 102.73-110.56 Mbp fragment of chromosome 13 and characterized by altered sensitivity of 5-HT

Indexed as

AnimalsAntidepressive Agents, Second-GenerationCerebral CortexFluoxetineHippocampusMaleMiceMice, Inbred CBAReceptor, Serotonin, 5-HT1ASelective Serotonin Reuptake InhibitorsAntidepressive Agents, Second-GenerationFluoxetineHtr1a protein, mouseReceptor, Serotonin, 5-HT1ASelective Serotonin Reuptake Inhibitors5-HT1A receptorantidepressants resistancefluoxetineFreud-1miceserotoninSSRI

Identifiers

PMID33233644

DOI10.3390/ijms21228784

PMCPMC7699677

OpenAlexW3102542961

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.