Evidence map›Paper›PMID 33233634›Full record

ReviewChildren (Basel, Switzerland)2020

Treatment of Complex Regional Pain Syndrome in Children and Adolescents: A Structured Literature Scoping Review.

Andrea Vescio, Gianluca Testa, Annalisa Culmone, Marco Sapienza, Fabiana Valenti, Fabrizio Di Maria, Vito Pavone

Abstract readReview
In one paragraph

Review in Children (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Treating CRPS and FNSD in an Adolescent: A Case Study.Journal of clinical psychology in medical settings · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Bone Development and Disease in Infants.Children (Basel, Switzerland) · 2022
    Article
  10. Article
  11. Ballet foot in a boy.International journal of rheumatic diseases · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Andrea VescioDepartment of General Surgery and Medical Surgical Specialties, Section of Orthopaedics and Traumatology, Surgery, AOU Policlinico-Vittorio Emanuele, University of Catania, 95123 Catania, Italy.ORCID 0000-0002-1677-927X
Gianluca TestaDepartment of General Surgery and Medical Surgical Specialties, Section of Orthopaedics and Traumatology, Surgery, AOU Policlinico-Vittorio Emanuele, University of Catania, 95123 Catania, Italy.ORCID 0000-0001-5246-9714
Annalisa CulmoneDepartment of General Surgery and Medical Surgical Specialties, Section of Orthopaedics and Traumatology, Surgery, AOU Policlinico-Vittorio Emanuele, University of Catania, 95123 Catania, Italy.
Marco SapienzaDepartment of General Surgery and Medical Surgical Specialties, Section of Orthopaedics and Traumatology, Surgery, AOU Policlinico-Vittorio Emanuele, University of Catania, 95123 Catania, Italy.ORCID 0000-0002-8311-9132
Fabiana ValentiDepartment of General Surgery and Medical Surgical Specialties, Section of Orthopaedics and Traumatology, Surgery, AOU Policlinico-Vittorio Emanuele, University of Catania, 95123 Catania, Italy.
Fabrizio Di MariaDepartment of General Surgery and Medical Surgical Specialties, Section of Orthopaedics and Traumatology, Surgery, AOU Policlinico-Vittorio Emanuele, University of Catania, 95123 Catania, Italy.
Vito PavoneDepartment of General Surgery and Medical Surgical Specialties, Section of Orthopaedics and Traumatology, Surgery, AOU Policlinico-Vittorio Emanuele, University of Catania, 95123 Catania, Italy.ORCID 0000-0001-5664-8066

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundComplex regional pain syndrome (CRPS) is characterized by chronic, spontaneous and provoked pain of the distal extremities whose severity is disproportionate to the triggering event. Diagnosis and treatment are still debated and multidisciplinary. The purpose of this systematic review is to analyze the available literature to provide an update on the latest evidence related to the treatment of CRPS in growing age.

methodsData extraction was performed independently by three reviewers based on predefined criteria and the methodologic quality of included studies was quantified by the Newcastle-Ottawa Quality Assessment Scale Cohort Studies.

resultsAt the end of the first screening, following the previously described selection criteria, we selected n = 103 articles eligible for full-text reading. Ultimately, after full-text reading and a reference list check, we selected n = 6. The articles focused on physical (PT), associated with cognitive behavioral (CBT) and pharmacological (PhT) treatments. The combination of PT + CBT shows the most efficacy as suggested, but a commonly accepted protocol has not been developed.

conclusionsPhysical therapy in association with occupational and cognitive behavioral treatment is the recommended option in the management of pediatric CPRS. Pharmacological therapy should be reserved for refractory and selected patients. The design and development of a standard protocol are strongly suggested.

Indexed as

cognitive behavioral therapycomplex regional pain syndromedrugsgrowing agemultidisciplinaryoccupational therapypediatricpharmacological treatmentphysical therapyreflex sympathetic dystrophy

Identifiers

PMID33233634
PMCPMC7699814

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.