ArticleInternational journal of molecular sciences2020
Obese Mice with Dyslipidemia Exhibit Meibomian Gland Hypertrophy and Alterations in Meibum Composition and Aqueous Tear Production.
Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 35 citations in OpenAlex.
- Obesity and Eye Diseases.Nutrients · 2026Review
- Preservative-free latanoprost induces meibomian gland dysfunction through inflammatory and oxidative stress pathways.BMC pharmacology & toxicology · 2026Article
- Gut-ocular surface axis in dry eye disease: phenotype-specific mechanisms, evidence, and microbiome-targeted interventions.Frontiers in cellular and infection microbiology · 2026Review
- Development and validation of a risk prediction model for dry eye disease in myopic children.Frontiers in medicine · 2026Article
- Intermittent fasting ameliorates diabetes-induced meibomian gland dysfunction in mice.International journal of ophthalmology · 2026Article
- Sodium butyrate modulates ocular surface microbiome and attenuates inflammation of meibomian gland dysfunction in ApoEMicrobiome · 2025Article
- The role of childhood overweight in meibomian gland dysfunction and dry eye disease in Chinese children.BMC ophthalmology · 2025Article
- Photothermal-Responsive Soluble Microneedle Patches for Meibomian Gland Dysfunction Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Association between Disorders of Lipid Metabolism and Oculopathy: An Overview.International journal of medical sciences · 2025Review
- Association between insulin-like growth factor-1 and ocular surface parameters in obese prepubertal boys.European journal of pediatrics · 2024Article
- Article
- Impact of Dyslipidemia on Tear Film and Meibomian Gland Dysfunction: A Cross-Sectional Study of the Interplay between Serum Lipid Profile and Ocular Surface Health.Journal of ophthalmology · 2024Article
- Alteration of Meibum Lipidomics Profiling in Patients With Chronic Ocular Graft-Versus-Host Disease.Investigative ophthalmology & visual science · 2023Article
- Dysregulation of Lipid Metabolism in Aging Meibomian Glands and Its Molecular Markers.International journal of molecular sciences · 2023Article
- Meibomian gland stem/progenitor cells: The hunt for gland renewal.The ocular surface · 2023Article
- Dyslipidemia Exacerbates Meibomian Gland Dysfunction: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2023Review
- Article
- A Low-Fat/Sucrose Diet Rich in Complex Carbohydrates Reverses High-Fat/Sucrose Diet-Induced Corneal Dysregulation.International journal of molecular sciences · 2023Article
- High-fat intake reshapes the circadian transcriptome profile and metabolism in murine meibomian glands.Frontiers in nutrition · 2023Article
- Article
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundDyslipidemia may be linked to meibomian gland dysfunction (MGD) and altered meibum lipid composition. The purpose was to determine if plasma and meibum cholesteryl esters (CE), triglycerides (TG), ceramides (Cer) and sphingomyelins (SM) change in a mouse model of diet-induced obesity where mice develop dyslipidemia.
methodsMale C57/BL6 mice (8/group, age = 6 wks) were fed a normal (ND; 15% kcal fat) or an obesogenic high-fat diet (HFD; 42% kcal fat) for 10 wks. Tear production was measured and meibography was performed. Body and epididymal adipose tissue (eAT) weights were determined. Nano-ESI-MS/MS and LC-ESI-MS/MS were used to detect CE, TG, Cer and SM species. Data were analyzed by principal component analysis, Pearson's correlation and unpaired
resultsCompared to ND mice, HFD mice gained more weight and showed heavier eAT and dyslipidemia with higher levels of plasma CE, TG, Cer and SM. HFD mice had hypertrophic meibomian glands, increased levels of lipid species acylated by saturated fatty acids in plasma and meibum and excessive tear production.
conclusionsThe majority of meibum lipid species with saturated fatty acids increased with HFD feeding with evidence of meibomian gland hypertrophy and excessive tearing. The dyslipidemia is associated with altered meibum composition, a key feature of MGD.
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