Evidence map›Paper›PMID 33233517›Full record

ReviewGenes2020

At the X-Roads of Sex and Genetics in Pulmonary Arterial Hypertension.

Meghan M Cirulis, Mark W Dodson, Lynn M Brown, Samuel M Brown, Tim Lahm, Greg Elliott

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Genes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. [Protective effects of 2-methoxyestradiol against hypoxic pulmonary hypertension in neonatal rats].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024
    Article
  4. Review
  5. Review
  6. Sex and gender in pulmonary arterial hypertension.European respiratory review : an official journal of the European Respiratory Society · 2021
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Meghan M CirulisDivision of Pulmonary, Critical Care and Occupational Medicine, University of Utah, Salt Lake City, UT 84132, USA.ORCID 0000-0003-1520-1713
Mark W DodsonDivision of Pulmonary, Critical Care and Occupational Medicine, University of Utah, Salt Lake City, UT 84132, USA.
Lynn M BrownDivision of Pulmonary, Critical Care and Occupational Medicine, University of Utah, Salt Lake City, UT 84132, USA.
Samuel M BrownDivision of Pulmonary, Critical Care and Occupational Medicine, University of Utah, Salt Lake City, UT 84132, USA.
Tim LahmDivision of Pulmonary, Critical Care, Sleep and Occupational Medicine, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Greg ElliottDivision of Pulmonary, Critical Care and Occupational Medicine, University of Utah, Salt Lake City, UT 84132, USA.
University of Utah · USRichard L. Roudebush VA Medical Center · US

Funding

Mechanisms of Right Ventricle Adaptation to Pulmonary HypertensionR01HL144727 · NHLBI · NATIONAL JEWISH HEALTH · PI Tim Lahm · 2019 to 2026
$4.7M
Study of Treatment's Echocardiographic Mechanisms (CLOVERS-STEM)R01HL144624 · NHLBI · IHC HEALTH SERVICES, INC. · PI BROWN, SAMUEL MORRIS · 2019 to 2022
$1.8M
Hypoxia-mediated protective estrogen receptor signaling in pulmonary hypertensionI01BX002042 · VA · VA EASTERN COLORADO HEALTH CARE SYSTEM · PI Tim Lahm · 2014 to 2026
–
BLRD VA I01 BX002042NHLBI NIH HHS R01 HL144624NHLBI NIH HHS R01 HL144727
6 · The paper itself

Abstract

Group 1 pulmonary hypertension (pulmonary arterial hypertension; PAH) is a rare disease characterized by remodeling of the small pulmonary arteries leading to progressive elevation of pulmonary vascular resistance, ultimately leading to right ventricular failure and death. Deleterious mutations in the serine-threonine receptor bone morphogenetic protein receptor 2 (

Indexed as

AnimalsBone Morphogenetic Protein Receptors, Type IIEstrogensFemaleHumansMalePulmonary Arterial HypertensionSignal TransductionBMPR2 protein, humanBone Morphogenetic Protein Receptors, Type IIEstrogensbone morphogenetic protein receptor type 2estradiolestrogenfamilialgenderheritablePAHpenetrance

Identifiers

PMID33233517
PMCPMC7699559
OpenAlexW3098619255

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.