Evidence map›Paper›PMID 33233493›Full record

ArticleInternational journal of molecular sciences2020

The Importance of AGO 1 and 4 in Post-Transcriptional Gene Regulatory Function of tRF5-GluCTC, an Respiratory Syncytial Virus-Induced tRNA-Derived RNA Fragment.

Eun-Jin Choi, Junping Ren, Ke Zhang, Wenzhe Wu, Yong Sun Lee, Inhan Lee, Xiaoyong Bao

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 54 citations in OpenAlex.

  1. Article
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  6. The Impact ofViruses · 2025
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  17. Frontiers in immunology · 2023
    Article
  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Eun-Jin ChoiDepartment of Pediatrics, The University of Texas Medical Branch, Galveston, TX 77555, USA.
Junping RenDepartment of Pediatrics, The University of Texas Medical Branch, Galveston, TX 77555, USA.
Ke ZhangDepartment of Chemistry, The University of Houston Clear Lake, Clear Lake, TX 77058, USA.
Wenzhe WuDepartment of Pediatrics, The University of Texas Medical Branch, Galveston, TX 77555, USA.
Yong Sun LeeDepartment of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Gyeonggi-do 10408, Korea.ORCID 0000-0001-9689-3410
Inhan LeemiRcore, Ann Arbor, MI 48105, USA.
Xiaoyong BaoDepartment of Pediatrics, The University of Texas Medical Branch, Galveston, TX 77555, USA.ORCID 0000-0002-6884-2584
The University of Texas Medical Branch at Galveston · USNational Cancer Center · KRUniversity of Houston - Clear Lake · US

Funding

tRNA-derived RNA Fragments (tRFs) and their Functions in Respiratory Syncytial Virus (RSV) InfectionR01AI116812 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI BAO, XIAOYONG · 2016 to 2020
$1.9M
Flight Attendant Medical Research Institute 160020NIAID NIH HHS R01 AI116812NIH HHS 1R21AG069226NIH HHS R01 AI116812
6 · The paper itself

Abstract

Respiratory syncytial virus (RSV) is the most common cause of lower respiratory tract infection in infants, the elderly, and immune-compromised patients. It is also a significant contributor to upper respiratory tract infection in the pediatric population. However, its disease mechanisms are still largely unknown. We have recently shown that a tRNA-derived RNA fragment (

Indexed as

Gene SilencingA549 CellsArgonaute ProteinsEukaryotic Initiation FactorsGenes, ReporterHEK293 CellsHost-Pathogen InteractionsHumansLuciferasesRespiratory Syncytial Virus, HumanRNA, TransferRNA, UntranslatedSignal TransductionViral LoadViral Structural ProteinsVirus ReplicationAGO1 protein, humanAGO2 protein, humanAGO3 protein, humanAGO4 protein, humanArgonaute ProteinsEukaryotic Initiation FactorsLuciferasesP protein, human respiratory syncytial virusRNA, TransferRNA, UntranslatedViral Structural Proteinsargonautepost-transcriptional gene regulationRSVtRNA-derived RNA fragments

Identifiers

PMID33233493
PMCPMC7699471
OpenAlexW3099516861

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.