Evidence map›Paper›PMID 33233413›Full record

ReviewMaterials (Basel, Switzerland)2020

Cellulose-Based Hydrogels as Sustained Drug-Delivery Systems.

Diana Elena Ciolacu, Raluca Nicu, Florin Ciolacu

Abstract readReview
In one paragraph

Review in Materials (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed.

  1. Article
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  4. Polysaccharides and carbohydrate polymers: innovations from nature to industry.Journal of the science of food and agriculture · 2026
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21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Diana Elena Ciolacu"Petru Poni" Institute of Macromolecular Chemistry, 700487 Iasi, Romania.ORCID 0000-0002-0906-9835
Raluca Nicu"Petru Poni" Institute of Macromolecular Chemistry, 700487 Iasi, Romania.ORCID 0000-0002-5608-4827
Florin CiolacuNatural and Synthetic Polymers Department, "Gheorghe Asachi" Technical University of Iasi, 700050 Iasi, Romania.ORCID 0000-0001-9178-6317

Funding

Romanian Ministry of Research and Innovation PN-III-P1-1.2-PCCDI-2017-0697/13PCCDI/2018
6 · The paper itself

Abstract

Hydrogels, three-dimensional (3D) polymer networks, present unique properties, like biocompatibility, biodegradability, tunable mechanical properties, sensitivity to various stimuli, the capacity to encapsulate different therapeutic agents, and the ability of controlled release of the drugs. All these characteristics make hydrogels important candidates for diverse biomedical applications, one of them being drug delivery. The recent achievements of hydrogels as safe transport systems, with desired therapeutic effects and with minimum side effects, brought outstanding improvements in this area. Moreover, results from the utilization of hydrogels as target therapy strategies obtained in clinical trials are very encouraging for future applications. In this regard, the review summarizes the general concepts related to the types of hydrogel delivery systems, their properties, the main release mechanisms, and the administration pathways at different levels (oral, dermal, ocular, nasal, gastrointestinal tract, vaginal, and cancer therapy). After a general presentation, the review is focused on recent advances in the design, preparation and applications of innovative cellulose-based hydrogels in controlled drug delivery.

Indexed as

cellulosedrug delivery systemshydrogelspH-responsivestimuli-responsive hydrogelstarget therapythermo-responsive

Identifiers

PMID33233413
PMCPMC7700533

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.