Evidence map›Paper›PMID 33233405›Full record

ArticleJournal of clinical medicine2020

An Original ELISA-Based Multiplex Method for the Simultaneous Detection of 5 SARS-CoV-2 IgG Antibodies Directed against Different Antigens.

Constant Gillot, Jonathan Douxfils, Julie Cadrobbi, Kim Laffineur, Jean-Michel Dogné, Marc Elsen, Christine Eucher, Sabrina Melchionda, Élise Modaffarri, Marie Tré-Hardy and 1 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
0.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Observational
  3. Seroprevalence of SARS-CoV-2 in hospital workers in the southern region of Minas Gerais state in Brazil: An analysis of the pre-vaccine period.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023
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  10. Review
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  16. Performance of a SARS CoV-2 antibody ELISA based on simultaneous measurement of antibodies against the viral nucleoprotein and receptor-binding domain.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2021
    Article
  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Constant GillotDepartment of Pharmacy, Namur Research Institute for Life Sciences, University of Namur, B-5000 Namur, Belgium.
Jonathan DouxfilsDepartment of Pharmacy, Namur Research Institute for Life Sciences, University of Namur, B-5000 Namur, Belgium.ORCID 0000-0002-7644-5298
Julie CadrobbiDepartment of Laboratory Medicine, Clinique St-Luc Bouge, 5004 Namur, Belgium.
Kim LaffineurDepartment of Laboratory Medicine, Clinique St-Luc Bouge, 5004 Namur, Belgium.
Jean-Michel DognéDepartment of Pharmacy, Namur Research Institute for Life Sciences, University of Namur, B-5000 Namur, Belgium.
Marc ElsenDepartment of Laboratory Medicine, Clinique St-Luc Bouge, 5004 Namur, Belgium.
Christine EucherDepartment of Laboratory Medicine, Clinique St-Luc Bouge, 5004 Namur, Belgium.
Sabrina MelchiondaCentral Laboratory Department, Qualiblood sa, 5000 Namur, Belgium.
Élise ModaffarriCentral Laboratory Department, Qualiblood sa, 5000 Namur, Belgium.
Marie Tré-HardyDepartment of Pharmacy, Namur Research Institute for Life Sciences, University of Namur, B-5000 Namur, Belgium.
Julien FavresseDepartment of Pharmacy, Namur Research Institute for Life Sciences, University of Namur, B-5000 Namur, Belgium.
Clinique Saint-Joseph · BEUniversity of Namur · BEUniversité Libre de Bruxelles · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Strategies to detect SARS-CoV-2 are increasingly being developed. Among them, serological methods have been developed. Nevertheless, although these may present an interesting clinical performance, they are often directed against only one antigen. This study aims at evaluating the clinical performance of an innovative multiplex immunoassay (i.e., CoViDiag assay) detecting simultaneously the presence of antibodies directed against N, S1, S2, RBD and NTD antigens. Sensitivity was evaluated in 135 samples obtained from 94 rRT-PCR confirmed coronavirus disease 2019 (COVID-19) patients. Non-SARS-CoV-2 sera (

Indexed as

COVID-19kineticsmultiplexSARS-CoV-2serology

Identifiers

PMID33233405
PMCPMC7700260
OpenAlexW3108147319

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.