Evidence map›Paper›PMID 33232892›Full record

ArticleEpilepsy & behavior : E&B2020

EEG markers predictive of epilepsy risk in pediatric cerebral malaria - A feasibility study.

Archana A Patel, Ali Jannati, Sameer C Dhamne, Monica Sapuwa, Elizabeth Kalanga, Maitreyi Mazumdar, Gretchen L Birbeck, Alexander Rotenberg

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epilepsy & behavior : E&B, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05746819 (An MRI Ancillary Study of a Malaria Fever Randomized Controlled Trial), which is not on this map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05746819 completednot on this mapstarted 2021, after this paper: background citation

An MRI Ancillary Study of a Malaria Fever Randomized Controlled Trial (RCT)

TypeobservationalSponsorUniversity of RochesterRan2021 to 2024Enrolled181ConditionsBrain Injuries, Malaria, MRI Imaging, Neurocognitive DeficitsArmsAggressive antipyretics therapy of fever vs usual care in the Malaria RCT study
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Observational
  3. Article
  4. Review
  5. Article
  6. Observational
  7. Epileptogenesis in Common Parasitic Infections.Current neurology and neuroscience reports · 2022
    Review
  8. Article
  9. Selected Molecular Targets for Antiepileptogenesis.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Archana A PatelDivision of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: archana.patel@childrens.harvard.edu.
Ali JannatiDivision of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; F.M. Kirby Neurobiology Center, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Sameer C DhamneDivision of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; F.M. Kirby Neurobiology Center, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Monica SapuwaBlantyre Malaria Project, Queen Elizabeth Central Hospital, Blantyre, Malawi.
Elizabeth KalangaBlantyre Malaria Project, Queen Elizabeth Central Hospital, Blantyre, Malawi.
Maitreyi MazumdarDepartment of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Gretchen L BirbeckBlantyre Malaria Project, Queen Elizabeth Central Hospital, Blantyre, Malawi; Epilepsy Division, Department of Neurology, University of Rochester, Rochester, NY, USA.
Alexander RotenbergDivision of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; F.M. Kirby Neurobiology Center, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.

Funding

Cortical Plasticity in Autism Spectrum DisordersR01MH100186 · NIMH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI ROTENBERG, ALEXANDER · 2014 to 2018
$2.2M
Does arsenic increase risk of neural tube defects in a highly-exposed population?R01ES026317 · NIEHS · BOSTON CHILDREN'S HOSPITAL · PI MAZUMDAR, MAITREYI · 2016 to 2020
$2.2M
Mapping progressive loss of intracortical inhibition by TMS and EEG in posttraumatic epileptogenesisR01NS088583 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI ROTENBERG, ALEXANDER · 2015 to 2019
$1.9M
Is Cerebral Malaria a Risk Factor for Epilepsy?K23NS046086 · NINDS · MICHIGAN STATE UNIVERSITY · PI BIRBECK, GRETCHEN L. · 2004 to 2008
$798k
NIEHS NIH HHS R01 ES026317NIMH NIH HHS R01 MH100186NINDS NIH HHS K23 NS046086NINDS NIH HHS R01 NS088583
6 · The paper itself

Abstract

objectiveCerebral malaria (CM) affects 500,000 million children annually, 10% whom develop epilepsy within two years. Acute identification of biomarkers for post-CM epilepsy would allow for follow-up of the highest risk populations in resource-limited regions. We investigated the utility of electroencephalogram (EEG) and clinical metrics obtained during acute CM infection for predicting epilepsy.

methodsWe analyzed 70 EEGs recorded within 24 h of admission for CM hospitalization obtained during the Blantyre Malaria Project Epilepsy Study (2005-2007), a prospective cohort study of pediatric CM survivors. While all studies underwent spectral analyses for comparisons of mean power band frequencies, a subset of EEGs from the 10 subjects who developed epilepsy and 10 age- and sex-matched controls underwent conventional visual analysis. Findings were tested for relationships to epilepsy outcomes.

resultsTen of the 70 subjects developed epilepsy. There were no significant differences between groups that were analyzed via visual EEG review; however, spectral EEG analyses revealed a significantly higher gamma-delta power ratio in CM survivors who developed epilepsy (0.23 ± 0.10) than in those who did not (0.16 ± 0.06), p = 0.003. Excluding potential confounders, multivariable logistic-regression analyses found relative gamma power (p = 0.003) and maximum temperature during admission (p = 0.03) significant and independent predictors of post-CM epilepsy, with area under receiver operating characteristics (AUROC) curve of 0.854.

conclusionsWe found that clinical and EEG metrics acquired during acute CM presentation confer risk of post-CM epilepsy. Further studies are required to investigate the utility of gamma activity as a potential biomarker of epileptogenesis and study this process over time. Additionally, resource limitations currently prevent follow-up of all CM cases to surveil for epilepsy, and identification of acute biomarkers in this population would offer the opportunity to allocate resources more efficiently.

Indexed as

EpilepsyMalaria, CerebralBiomarkersChildElectroencephalographyFeasibility StudiesHumansProspective StudiesBiomarkersBiomarkersCerebral malariaEEGEpilepsyPediatric

Identifiers

PMID33232892
PMCPMC7736081

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.