Evidence map›Paper›PMID 33232788›Full record

ArticleCancer letters2021

Inhibition of adjuvant-induced TAM receptors potentiates cancer vaccine immunogenicity and therapeutic efficacy.

Diana Llopiz, Marta Ruiz, Leyre Silva, David Repáraz, Belén Aparicio, Josune Egea, Juan J Lasarte, Esther Redin, Alfonso Calvo, Matthew Angel and 3 more

Open access · greenAbstract read
In one paragraph

Article in Cancer letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Harnessing myeloid cells in cancer.Molecular cancer · 2025
    Review
  3. Review
  4. Review
  5. Neoantigens as potential vaccines in hepatocellular carcinoma.Journal for immunotherapy of cancer · 2022
    Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Diana LlopizCentro de Investigación Médica Aplicada (CIMA), Universidad de Navarra, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Spain; IdiSNA, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain.
Marta RuizCentro de Investigación Médica Aplicada (CIMA), Universidad de Navarra, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Spain; IdiSNA, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain.
Leyre SilvaCentro de Investigación Médica Aplicada (CIMA), Universidad de Navarra, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Spain; IdiSNA, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain.
David RepárazCentro de Investigación Médica Aplicada (CIMA), Universidad de Navarra, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Spain; IdiSNA, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain.
Belén AparicioCentro de Investigación Médica Aplicada (CIMA), Universidad de Navarra, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Spain; IdiSNA, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain.
Josune EgeaCentro de Investigación Médica Aplicada (CIMA), Universidad de Navarra, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Spain; IdiSNA, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain.
Juan J LasarteCentro de Investigación Médica Aplicada (CIMA), Universidad de Navarra, Spain; IdiSNA, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain.
Esther RedinCentro de Investigación Médica Aplicada (CIMA), Universidad de Navarra, Spain; IdiSNA, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain; CIBERONC, ISCIII, Madrid, Spain; Department of Pathology, Anatomy and Physiology, School of Medicine, University of Navarra, Pamplona, Spain.
Alfonso CalvoCentro de Investigación Médica Aplicada (CIMA), Universidad de Navarra, Spain; IdiSNA, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain; CIBERONC, ISCIII, Madrid, Spain; Department of Pathology, Anatomy and Physiology, School of Medicine, University of Navarra, Pamplona, Spain.
Matthew AngelVaccine Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA; Center for Cancer Research Collaborative Bioinformatics Resource, Leidos Biomedical Research, Inc., FNLCR, Frederick, MD, USA.
Jay A BerzofskyVaccine Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
David StroncekCenter for Cellular Engineering, Department of Transfusion Medicine, NIH Clinical Center, Bethesda, MD, USA.
Pablo SarobeCentro de Investigación Médica Aplicada (CIMA), Universidad de Navarra, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Spain; IdiSNA, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain. Electronic address: psarobe@unav.es.
Navarre Institute of Health Research · ESInstituto de Salud Carlos III · ESLeidos (United States) · USNational Cancer Institute · USNational Institutes of Health Clinical Center · US

Funding

Vaccine and immunotherapy strategies for cancer and viruses causing cancerZIASC004020 · NCI · DIVISION OF CLINICAL SCIENCES - NCI · PI BERZOFSKY, JAY A · 2009 to 2025
$51.8M
Protective Role of Nonclassical Monocytes in Immunotherapies for Solid CancersU01CA224766 · NCI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI HEDRICK, CATHERINE C, KAPLAN, ROSANDRA · 2018 to 2021
$1.4M
Development of novel cell and gene therapiesZIACL002120 · CLC · CLINICAL CENTER · PI STRONCEK, DAVID · 2009 to 2025
$0k
Intramural NIH HHS ZIA CL002120NCI NIH HHS U01 CA224766
6 · The paper itself

Abstract

Analyzing immunomodulatory elements operating during antitumor vaccination in prostate cancer patients and murine models we identified IL-10-producing DC as a subset with poorer immunogenicity and clinical efficacy. Inhibitory TAM receptors MER and AXL were upregulated on murine IL-10

Indexed as

Adjuvants, ImmunologicAnimalsAxl Receptor Tyrosine KinaseCancer VaccinesCD8-Positive T-LymphocytesCell Line, Tumorc-Mer Tyrosine KinaseDendritic CellsFemaleGene Expression Regulation, NeoplasticHumansImiquimodImmunogenicity, VaccineImmunotherapyInterleukin-10Lymphocytes, Tumor-InfiltratingAdjuvants, ImmunologicAxl Receptor Tyrosine KinaseCancer Vaccinesc-Mer Tyrosine KinaseImiquimodInterleukin-10MERTK protein, humanMertk protein, mousePoly I-CProto-Oncogene ProteinsPyrimidinesQuinolinesReceptor Protein-Tyrosine KinasesRXDX-106Dendritic cellsIL-10MERTAM receptorsTherapeutic vaccination

Identifiers

PMID33232788
PMCPMC8006848
OpenAlexW3106919519

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.