Evidence map›Paper›PMID 33232669›Full record

ArticleDevelopmental cell2020

Tyramine Acts Downstream of Neuronal XBP-1s to Coordinate Inter-tissue UPR

Neşem P Özbey, Soudabeh Imanikia, Christel Krueger, Iris Hardege, Julia Morud, Ming Sheng, William R Schafer, M Olivia Casanueva, Rebecca C Taylor

Open access · hybridAbstract read
In one paragraph

Article in Developmental cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 67 citations in OpenAlex.

  1. Article
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  3. Application ofBiomolecules & therapeutics · 2026
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  5. Review
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  7. Article
  8. Distinct responses to non-autonomous UPRCommunications biology · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. UPReLife · 2024
    Article
  19. Article
  20. Biological resilience in health and disease.Disease models & mechanisms · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Neşem P ÖzbeyNeurobiology Division, MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
Soudabeh ImanikiaNeurobiology Division, MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
Christel KruegerEpigenetics Programme, The Babraham Institute, Babraham CB22 3AT, UK.
Iris HardegeNeurobiology Division, MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
Julia MorudNeurobiology Division, MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
Ming ShengNeurobiology Division, MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
William R SchaferNeurobiology Division, MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
M Olivia CasanuevaEpigenetics Programme, The Babraham Institute, Babraham CB22 3AT, UK.
Rebecca C TaylorNeurobiology Division, MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK. Electronic address: rtaylor@mrc-lmb.cam.ac.uk.
MRC Laboratory of Molecular Biology · GBBabraham Institute · GB

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Medical Research Council MC_UP_1201/7NIH HHS P40 OD010440
6 · The paper itself

Abstract

In C. elegans, expression of the UPR

Indexed as

Unfolded Protein ResponseAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsCarrier ProteinsFeeding BehaviorIntestinal MucosaLongevityNeuronsRNA SplicingStress, PhysiologicalTranscriptomeTyramineCaenorhabditis elegans ProteinsCarrier ProteinsTyramineXBP-1 protein, C elegansagingC. elegansER stressneurobiologyproteostasissignalingstress response

Identifiers

PMID33232669
PMCPMC7758879
OpenAlexW3109508248

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.