ArticleMedical physics2021
Assessment of DNA damage with an adapted independent reaction time approach implemented in Geant4-DNA for the simulation of diffusion-controlled reactions between radio-induced reactive species and a chromatin fiber.
Article in Medical physics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Gold Nanoparticle-Mediated DNA Damage Under FLASH Electron-Beam Irradiation: A Monte Carlo Study.Nanomaterials (Basel, Switzerland) · 2026Article
- Ultra-high dose rate dependent modeling of plasmid DNA damage with TOPAS-nBio.Physics in medicine and biology · 2026Article
- The role of coating layers in gold nanorods' radioenhancement: a Monte Carlo analysis.Nanoscale advances · 2025Article
- Recent updates of the MPEXS2.1-DNA Monte Carlo code for simulations of water radiolysis under ion irradiation.Scientific reports · 2025Article
- TOPAS-Tissue: A Framework for the Simulation of the Biological Response to Ionizing Radiation at the Multi-Cellular Level.International journal of molecular sciences · 2024Article
- Review of chemical models and applications in Geant4-DNA: Report from the ESA BioRad III Project.Medical physics · 2024Review
- Simulation of DNA damage using Geant4-DNA: an overview of the "molecularDNA" example application.Precision radiation oncology · 2023Article
- Radical Production with Pulsed Beams: Understanding the Transition to FLASH.International journal of molecular sciences · 2022Article
- Review of the Geant4-DNA Simulation Toolkit for Radiobiological Applications at the Cellular and DNA Level.Cancers · 2021Review
- Article
- TOPAS-nBio validation for simulating water radiolysis and DNA damage under low-LET irradiation.Physics in medicine and biology · 2021Article
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Authors and funding
11 authors at 7 institutions in 5 countries.
Funding
Abstract
purposeSimulation of indirect damage originating from the attack of free radical species produced by ionizing radiation on biological molecules based on the independent pair approximation is investigated in this work. In addition, a new approach, relying on the independent pair approximation that is at the origin of the independent reaction time (IRT) method, is proposed in the chemical stage of Geant4-DNA.
methodsThis new approach has been designed to respect the current Geant4-DNA chemistry framework while proposing a variant IRT method. Based on the synchronous algorithm, this implementation allows us to access the information concerning the position of radicals and may make it more convenient for biological damage simulations. Estimates of the evolution of free species as well as biological hits in a segment of DNA chromatin fiber in Geant4-DNA were compared for the dynamic time step approach of the step-by-step (SBS) method, currently used in Geant4-DNA, and this newly implemented IRT.
resultsResults show a gain in computation time of a factor of 30 for high LET particle tracks with a better than 10% agreement on the number of DNA hits between the value obtained with the IRT method as implemented in this work and the SBS method currently available in Geant4-DNA.
conclusionOffering in Geant4-DNA more efficient methods for the chemical step based on the IRT method is a task in progress. For the calculation of biological damage, information on the position of chemical species is a crucial point. This can be achieved using the method presented in this paper.
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