ArticleJournal of clinical pathology1987
Monoclonal antibody L26: an antibody that is reactive with normal and neoplastic B lymphocytes in routinely fixed and paraffin wax embedded tissues.
Article in Journal of clinical pathology, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 119 citations in OpenAlex.
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- Inflammation in the pathogenesis of lyme neuroborreliosis.The American journal of pathology · 2015Article
- CD20-positive NK/T-cell lymphoma with indolent clinical course: report of case and review of literature.Diagnostic pathology · 2012Review
- CD20 Positive T Cell Lymphoma Involvement of Skin.Annals of dermatology · 2011Article
- The identification of irreversible rituximab-resistant lymphoma caused by CD20 gene mutations.Blood cancer journal · 2011Article
- Evaluation of B cell lymphoid infiltrates in bone marrow biopsies by morphology, immunohistochemistry, and molecular analysis.Journal of clinical pathology · 2000Article
- A new xenograft model of primary central nervous system lymphoma.Journal of neuro-oncology · 1999Article
- Ileocolic intussusception in adult due to malignant lymphoma in the cecum with intramural metastasis.Journal of gastroenterology · 1996Article
- Evidence for an abnormal profile of interleukin-4 (IL-4), IL-5, and gamma-interferon (gamma-IFN) in peripheral blood T cells from patients with allergic eosinophilic gastroenteritis.Journal of clinical immunology · 1994Article
- Immunohistochemical characterization of mononuclear cells in delayed hypersensitivity reactions to Paracoccidiodes brasiliensis (paracoccidioidin test).Mycopathologia · 1993Article
- Expression of vascular cell adhesion molecule (VCAM-1) in liver and pancreas allograft rejection.The American journal of pathology · 1993Article
- Chronic progressive sensory ataxic neuropathy: clinicopathological features of idiopathic and Sjögren's syndrome-associated cases.Journal of neurology · 1993Article
- Childhood lymphoma in Yorkshire.Journal of clinical pathology · 1992Article
- Expression of B-cell antigens by Hodgkin's and Reed-Sternberg cells.The American journal of pathology · 1991Article
- Interleukin-1 mRNA-expressing macrophages in human chronically inflamed gingival tissues.The American journal of pathology · 1991Article
- Twelve cases of Ki-1 positive anaplastic large cell lymphoma of skin.Journal of clinical pathology · 1991Article
- Antibody L26 recognizes an intracellular epitope on the B-cell-associated CD20 antigen.The American journal of pathology · 1990Article
- Relationship between high-grade lymphoma and low-grade B-cell mucosa-associated lymphoid tissue lymphoma (MALToma) of the stomach.The American journal of pathology · 1990Article
- Diagnosis of primary cerebral lymphoma with particular reference to CT-guided stereotactic biopsy.Virchows Archiv. A, Pathological anatomy and histopathology · 1990Article
- Diagnosis of myelomonocytic and macrophage neoplasms in routinely processed tissue biopsies with monoclonal antibody KP1.The American journal of pathology · 1989Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Formalin fixed and paraffin wax embedded tissue from 85 well characterised cases of non-Hodgkin's lymphoma and Hodgkin's disease were studied using the avidin-biotin-peroxidase complex technique. Among the non-Hodgkin's lymphomas all cases of B cell lymphoma were reactive with L26, a monoclonal antibody which is as yet an unclustered pan B cell reagent, with the exception of pre-B cell acute lymphoblastic leukaemia and malignant lymphoma plasmacytic. Eighteen well characterised cases of T cell lymphoma, selected to include tumours previously shown to exhibit cross reactivity with antibodies to fixation resistant B cell related antigens, were similarly studied. Neoplastic cells in all but one case were unstained by L26. Twenty seven cases of Hodgkin's disease were also examined. In five cases all Reed-Sternberg cells and their variants were strongly stained by L26; only a proportion of Reed-Sternberg cells and their variants were recognised in a further five cases. Monoclonal antibody L26 promises to be a valuable reagent for the diagnosis of malignant lymphoma in routinely fixed and paraffin wax embedded tissues. Its advantage lies in its sensitivity and greater B cell specificity than any of the B cell related reagents currently available for the study of malignant lymphoma in fixed tissues.
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