Evidence map›Paper›PMID 33232280›Full record

ArticleAging2020

Loss of Atg7 causes chaotic nucleosome assembly of mouse bone marrow CD11b

Yixuan Fang, Yue Gu, Lei Li, Lingjiang Zhu, Jiawei Qian, Chen Zhao, Li Xu, Wen Wei, Yanhua Du, Na Yuan and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Yixuan FangHematology Center of Cyrus Tang Medical Institute, Soochow University School of Medicine, Suzhou 215123, China.
Yue GuHematology Center of Cyrus Tang Medical Institute, Soochow University School of Medicine, Suzhou 215123, China.
Lei LiHematology Center of Cyrus Tang Medical Institute, Soochow University School of Medicine, Suzhou 215123, China.
Lingjiang ZhuHematology Center of Cyrus Tang Medical Institute, Soochow University School of Medicine, Suzhou 215123, China.
Jiawei QianHematology Center of Cyrus Tang Medical Institute, Soochow University School of Medicine, Suzhou 215123, China.
Chen ZhaoHematology Center of Cyrus Tang Medical Institute, Soochow University School of Medicine, Suzhou 215123, China.
Li XuHematology Center of Cyrus Tang Medical Institute, Soochow University School of Medicine, Suzhou 215123, China.
Wen WeiHematology Center of Cyrus Tang Medical Institute, Soochow University School of Medicine, Suzhou 215123, China.
Yanhua DuKey Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Orthopaedic Department of Tongji Hospital, the School of Life Sciences and Technology, Shanghai Key Laboratory of Signaling and Disease Research, Tongji University, Shanghai 200092, China.
Na YuanHematology Center of Cyrus Tang Medical Institute, Soochow University School of Medicine, Suzhou 215123, China.
Suping ZhangHematology Center of Cyrus Tang Medical Institute, Soochow University School of Medicine, Suzhou 215123, China.
Ye YuanDepartment of Orthopaedics, the Second Affiliated Hospital of Soochow University, Osteoporosis Institute of Soochow University, Suzhou 215004, China.
Youjia XuDepartment of Orthopaedics, the Second Affiliated Hospital of Soochow University, Osteoporosis Institute of Soochow University, Suzhou 215004, China.
Cizhong JiangKey Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Orthopaedic Department of Tongji Hospital, the School of Life Sciences and Technology, Shanghai Key Laboratory of Signaling and Disease Research, Tongji University, Shanghai 200092, China.
Jianrong WangHematology Center of Cyrus Tang Medical Institute, Soochow University School of Medicine, Suzhou 215123, China.
Soochow University · CNFirst Affiliated Hospital of Soochow University · CNSecond Affiliated Hospital of Soochow University · CNTongji Hospital · CNTongji University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atg7, a critical component of autophagy machinery, is essential for counteracting hematopoietic aging. However, the non-autophagic role of Atg7 on hematopoietic cells remains fundamentally unclear. In this study, we found that loss of Atg7, but not Atg5, another autophagy-essential gene, in the hematopoietic system reduces CD11b myeloid cellularity including CD11b

Indexed as

AnimalsAntigens, LyAutophagy-Related Protein 7Bone Marrow CellsCD11b AntigenMiceMice, KnockoutMyeloid CellsNucleosomesAntigens, LyAutophagy-Related Protein 7CD11b AntigenLy6G antigen, mouseNucleosomesagingAtg7histone H3.1nucleosome assembly

Identifiers

PMID33232280
PMCPMC7803583
OpenAlexW3107762695

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.