Evidence map›Paper›PMID 33232265›Full record

ArticleAging2020

Neurofilament degradation is involved in laparotomy-induced cognitive dysfunction in aged rats.

Yiyun Cao, Taotao Liu, Zhengqian Li, Jiao Yang, Lijun Ma, Xinning Mi, Ning Yang, Aihua Qi, Xiangyang Guo, Aizhong Wang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Yiyun CaoDepartment of Anesthesiology, Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200233, China.
Taotao LiuDepartment of Anesthesiology, Peking University Third Hospital, Beijing 100191, China.
Zhengqian LiDepartment of Anesthesiology, Peking University Third Hospital, Beijing 100191, China.
Jiao YangDepartment of Pharmacy, Sixth People’s Hospital East Campus Affiliated to Shanghai Jiao Tong University, Shanghai 200233, China.
Lijun MaDepartment of Medical Imaging, North Minzu University, Yinchuan, Ningxia 750021, China.
Xinning MiDepartment of Anesthesiology, Peking University Third Hospital, Beijing 100191, China.
Ning YangDepartment of Anesthesiology, Peking University Third Hospital, Beijing 100191, China.
Aihua QiDepartment of Anesthesiology, Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200233, China.
Xiangyang GuoDepartment of Anesthesiology, Peking University Third Hospital, Beijing 100191, China.
Aizhong WangDepartment of Anesthesiology, Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200233, China.
Peking University Third Hospital · CNPeking University · CNShanghai Jiao Tong University · CNShanghai Sixth People's Hospital · CNNorth Minzu University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Excessive neuroinflammatory responses play important roles in the development of postoperative cognitive dysfunction (POCD). Neurofilaments (NFs) were essential to the structure of axon and nerve conduction; and the abnormal degradation of NFs were always accompanied with degenerative diseases, which were also characterized by excessive neuroinflammatory responses in brain. However, it is still unclear whether the NFs were involved in the POCD. In this study, the LC-MS/MS method was used to explore the neuroinflammatory response and NFs of POCD in aged rats. Moreover, trichostatin A (TSA), an inflammation-related drug, was selected to test whether it could improve the surgery-induced cognitive dysfunction, inflammatory responses and NFs. Evident cognitive dysfunction, excessive microglia activation, neuroinflammatory responses and upregulated NFs in hippocampus were observed in the POCD group. TSA pretreatment could significantly mitigate these changes. The KEGG analysis revealed that nine pathways were enriched in the TSA + surgery group (versus the surgery group). Among them, two signaling pathways were closely related with the changes of NFs proteins. In conclusion, surgery could impair the cognitive function and aggravate neuroinflammation and NFs. The TSA could significantly improve these changes which might be related to the activation of the "focal adhesion" and "ECM-receptor interaction" pathways.

Indexed as

AnimalsCognitive DysfunctionHippocampusHydroxamic AcidsInflammationIntermediate FilamentsLaparotomyMicrogliaPostoperative ComplicationsRatsHydroxamic Acidstrichostatin Alaparotomyneurofilamentsneuroinflammatorypostoperative cognitive dysfunction (POCD)trichostatin A

Identifiers

PMID33232265
PMCPMC7803518
OpenAlexW3106572822

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.