Evidence map›Paper›PMID 33232109›Full record

ArticleACS chemical biology2020

Expansion of Gamma-Butyrolactone Signaling Molecule Biosynthesis to Phosphotriester Natural Products.

Yuta Kudo, Takayoshi Awakawa, Yi-Ling Du, Peter A Jordan, Kaitlin E Creamer, Paul R Jensen, Roger G Linington, Katherine S Ryan, Bradley S Moore

Open access · greenAbstract read
In one paragraph

Article in ACS chemical biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Microorganisms · 2025
    Article
  2. Article
  3. Article
  4. Small molecule inducers of actinobacteria natural product biosynthesis.Journal of industrial microbiology & biotechnology · 2023
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Yuta KudoCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093, United States.ORCID 0000-0002-1586-2004
Takayoshi AwakawaCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093, United States.ORCID 0000-0003-2575-3175
Yi-Ling DuDepartment of Chemistry, University of British Columbia, Vancouver, British Columbia V6T 1Z1, Canada.ORCID 0000-0001-7072-4803
Peter A JordanCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093, United States.
Kaitlin E CreamerCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093, United States.
Paul R JensenCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093, United States.
Roger G LiningtonDepartment of Chemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.ORCID 0000-0003-1818-4971
Katherine S RyanDepartment of Chemistry, University of British Columbia, Vancouver, British Columbia V6T 1Z1, Canada.ORCID 0000-0003-1643-1940
Bradley S MooreCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093, United States.ORCID 0000-0002-4652-1253
Scripps Institution of Oceanography · USUniversity of British Columbia · CASimon Fraser University · CA

Funding

Natural Product Genome MiningR01GM085770 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JENSEN, PAUL R, MOORE, BRADLEY S · 2009 to 2024
$5.8M
NIGMS NIH HHS R01 GM085770
6 · The paper itself

Abstract

Bacterial hormones, such as the iconic gamma-butyrolactone A-factor, are essential signaling molecules that regulate diverse physiological processes, including specialized metabolism. These low molecular weight compounds are common in

Indexed as

Signal Transduction4-ButyrolactoneBiological ProductsBridged Bicyclo Compounds, HeterocyclicEstersGenes, BacterialStreptomyces4-ButyrolactoneBiological ProductsBridged Bicyclo Compounds, HeterocyclicEsterssalinipostin A

Identifiers

PMID33232109
PMCPMC8217639
OpenAlexW3110199593

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.