Evidence map›Paper›PMID 33231844›Full record

ArticleHuman cell2021

A positive feedback loop between AlkB homolog 5 and miR-193a-3p promotes growth and metastasis in esophageal squamous cell carcinoma.

Jinliang Xue, Peng Xiao, Xiangdong Yu, Xiao Zhang

Abstract read
PubMed Publisher
In one paragraph

Article in Human cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 37 citations in OpenAlex.

  1. Review
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  8. Role of the mInternational journal of molecular medicine · 2025
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  12. Article
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  14. Biomolecules & biomedicine · 2024
    Article
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  19. The diverse role of RNA methylation in esophageal cancer.Acta biochimica et biophysica Sinica · 2023
    Review
  20. Roles of oncogenes in esophageal squamous cell carcinoma and their therapeutic potentials.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jinliang XueDepartment of Thoracic Surgery, Luoyang Central Hospital Affiliated To Zhengzhou University, No.288, Zhongzhou Middle Road, Luoyang City, 471009, Henan Province, China.
Peng XiaoDepartment of Thoracic Surgery, Luoyang Central Hospital Affiliated To Zhengzhou University, No.288, Zhongzhou Middle Road, Luoyang City, 471009, Henan Province, China.
Xiangdong YuDepartment of Thoracic Surgery, Luoyang Central Hospital Affiliated To Zhengzhou University, No.288, Zhongzhou Middle Road, Luoyang City, 471009, Henan Province, China.
Xiao ZhangDepartment of Thoracic Surgery, Luoyang Central Hospital Affiliated To Zhengzhou University, No.288, Zhongzhou Middle Road, Luoyang City, 471009, Henan Province, China. xiaozhang1984@126.com.ORCID http://orcid.org/0000-0002-0375-6706
Luoyang Central Hospital Affiliated to Zhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Esophageal squamous cell carcinoma (ESCC) is one of the most frequent malignancies worldwide. miR-193a-3p acts as an oncogene or tumor suppressor in different cancers. However, the functional role and regulatory mechanism of miR-193a-3p in ESCC remain to be elucidated. Our results demonstrated that miR-193a-3p expression was significantly upregulated and associated with advanced TNM stage, recurrence, and poor prognosis in ESCC patients. miR-193-3p targeted ALKBH5 and suppressed its expression. ALKBH5 inhibited miR-193a-3p expression in turn. ALKBH5 affected the primary miR-193a-3p processing by negatively regulating its m

Indexed as

AlkB Homolog 5, RNA DemethylaseCarcinoma, Squamous CellCell Line, TumorCell MovementCell ProliferationEsophageal NeoplasmsGene Expression Regulation, NeoplasticHumansMicroRNAsMolecular Targeted TherapyNeoplasm InvasivenessNeoplasm MetastasisAlkB Homolog 5, RNA DemethylaseMicroRNAsMIRN193 microRNA, humanm6A modificationmicroRNA processingPositive feedback loopRNA methylation

Identifiers

PMID33231844
OpenAlexW3108517909

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.