Evidence map›Paper›PMID 33231812›Full record

ArticleJournal of molecular neuroscience : MN2021

Sex-dimorphic Rostro-caudal Patterns of 5'-AMP-activated Protein Kinase Activation and Glucoregulatory Transmitter Marker Protein Expression in the Ventrolateral Ventromedial Hypothalamic Nucleus (VMNvl) in Hypoglycemic Male and Female Rats: Impact of Estradiol.

Ayed A Alshamrani, Khaggeswar Bheemanapally, Abdulrahman Alhamyani, Md Haider Ali, Prabhat R Napit, Md Main Uddin, A S M Hasan Mahmood, Mostafa M H Ibrahim, Karen P Briski

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular neuroscience : MN, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Ayed A Alshamrani *School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, 356 Bienville Building 1800 Bienville Drive, Monroe, 71201, USA.
Khaggeswar Bheemanapally *School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, 356 Bienville Building 1800 Bienville Drive, Monroe, 71201, USA.
Abdulrahman AlhamyaniSchool of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, 356 Bienville Building 1800 Bienville Drive, Monroe, 71201, USA.
Md Haider AliSchool of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, 356 Bienville Building 1800 Bienville Drive, Monroe, 71201, USA.
Prabhat R NapitSchool of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, 356 Bienville Building 1800 Bienville Drive, Monroe, 71201, USA.
Md Main UddinSchool of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, 356 Bienville Building 1800 Bienville Drive, Monroe, 71201, USA.
A S M Hasan MahmoodSchool of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, 356 Bienville Building 1800 Bienville Drive, Monroe, 71201, USA.
Mostafa M H IbrahimSchool of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, 356 Bienville Building 1800 Bienville Drive, Monroe, 71201, USA.
Karen P BriskiSchool of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, 356 Bienville Building 1800 Bienville Drive, Monroe, 71201, USA. briski@ulm.edu.ORCID http://orcid.org/0000-0002-7648-1395
University of Louisiana at Monroe · US

Funding

Estradiol Regulation of Hypothalamic Astrocyte GlycogenR01DK109382 · NIDDK · UNIVERSITY OF LOUISIANA AT MONROE · PI BRISKI, KAREN P · 2016 to 2020
$1.7M
NIDDK NIH HHS DK 109382NIDDK NIH HHS R01 DK109382
6 · The paper itself

Abstract

The ventromedial hypothalamic nucleus-ventrolateral part (VMNvl) is an estradiol-sensitive structure that controls sex-specific behavior. Electrical reactivity of VMNvl neurons to hypoglycemia infers that cellular energy stability is monitored there. Current research investigated the hypothesis that estradiol elicits sex-dimorphic patterns of VMNvl metabolic sensor activation and gluco-regulatory neurotransmission during hypoglycemia. Rostral-, middle-, and caudal-VMNvl tissue was separately micropunch-dissected from letrozole (Lz)- or vehicle-injected male and estradiol- or vehicle-implanted ovariectomized (OVX) female rats for Western blot analysis of total and phosphorylated 5'-AMP-activated protein kinase (AMPK) protein expression and gluco-stimulatory [neuronal nitric oxide synthase (nNOS); steroidogenic factor-1 (SF1) or -inhibitory (glutamate decarboxylase

Indexed as

AMP-Activated Protein Kinase KinasesAnimalsEstradiolFemaleGlucoseGlutamate DecarboxylaseHypoglycemiaHypothalamusInsulinMaleNitric Oxide Synthase Type IProtein KinasesRatsRats, Sprague-DawleyRNA Splicing FactorsSignal TransductionAMP-Activated Protein Kinase KinasesEstradiolGlucoseGlutamate Decarboxylaseglutamate decarboxylase 1glutamate decarboxylase 2InsulinNitric Oxide Synthase Type IProtein KinasesRNA Splicing FactorsSf1 protein, ratGlutamate decarboxylaseInsulin-induced hypoglycemiaLetrozolePhosphoAMPKVentrolateral ventromedial hypothalamic nucleus-ventrolateral part

Identifiers

PMID33231812
PMCPMC8076060
OpenAlexW3108211491

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.