Evidence map›Paper›PMID 33231793›Full record

ArticleInternational journal of clinical oncology2021

The metabolic syndrome is associated with the risk of urothelial carcinoma from a health examination database.

Hsiang-Ying Lee, Jia-Hong Tang, Yen-Hsu Chen, Wen-Jeng Wu, Yung-Shun Juan, Wei-Ming Li, Ta-Chien Chan

Abstract read
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In one paragraph

Article in International journal of clinical oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hsiang-Ying LeeGraduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Jia-Hong TangInstitute of Statistical Science, Academia Sinica, Taipei, Taiwan.
Yen-Hsu ChenKaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan.
Wen-Jeng WuDepartment of Urology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Yung-Shun JuanKaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan.
Wei-Ming LiDepartment of Urology, Ministry of Health and Welfare Pingtung Hospital, Pingtung, Taiwan.
Ta-Chien ChanResearch Center for Humanities and Social Sciences, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei, 115, Taiwan. dachianpig@gmail.com.ORCID http://orcid.org/0000-0002-1685-783X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe metabolic syndrome was associated with bladder cancer in the previous studies. However, there have no large-scale cohort studies to elucidate the relationship between metabolic syndromes and urothelial carcinoma including urinary bladder urothelial carcinoma (UBUC) and upper tract urothelial carcinoma (UTUC).

methodsWe analyze a population-based cohort study by using physical examination data and diagnosis of UC from the Taiwan Cancer Registry Database. Differences in demographic and clinical characteristics among UTUC and non-UTUC groups, UBUC and non-UBUC groups were compared. Odds ratios (ORs) for determining risk factors were estimated through the multiple logistic regression model.

resultsA total of 557,063 records for 211,319 participants which consisted of 31 UTUC and 309 UBUC met the eligibility criteria in this study. Our results showed that female are more likely to develop UTUC than male. As opposed to UTUC, male are more likely to develop UBUC than female. It also showed that participants smoked or chewed betel quid daily are more likely to develop UBUC. Age and estimated glomerular filtration rate (eGFR) are significantly increased the risk of developing UTUC. The association between the eGFR and risk of UTUC is stronger (P < 0.001) for eGFR < 45 (vs. eGFR ≥ 75, OR = 6.795; 95% CI 2.901-15.917). Metabolic syndrome is related to higher risk of UBUC incidence [OR was 1.373 (95% CI 1.104-1.707)].

conclusionsThere was a significant relationship between the incidence of UBUC and metabolic syndrome. Renal function impairment presents higher risk in both UBUC and UTUC development.

Indexed as

Carcinoma, Transitional CellMetabolic SyndromeCohort StudiesFemaleHumansMalePrognosisTaiwanBetel quidMetabolic syndromeRenal functionSmokingUrothelial carcinoma

Identifiers

PMID33231793

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.