A dual inhibitor targeting HMG-CoA reductase and histone deacetylase mitigates neurite degeneration in

Chin-Hsien Lin, Han-Yi Lin, Jim-Min Fang, Ching-Chow Chen

Open access · hybridAbstract read

In one paragraph

Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact, top 81% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Chin-Hsien LinDepartment of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei 100, Taiwan.

Han-Yi LinDepartment of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei 100, Taiwan.

Jim-Min FangDepartment of Chemistry, National Taiwan University, Taipei 106, Taiwan.

Ching-Chow ChenDepartment of Pharmacology, College of Medicine, National Taiwan University, Taipei 100, Taiwan.

National Taiwan University · TWNational Taiwan University Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease (PD) is among the most common neurodegenerative disorders, and its etiology involves both genetic and environmental factors. The leucine-rich repeat kinase (LRRK2) G2019S mutation is the most common genetic cause of familial and sporadic PD. Current treatment is limited to dopaminergic supplementation, as no disease-modifying therapy is available yet. Recent evidence reveals that HMG-CoA reductase (HMGR) inhibitors (statins) exert neuroprotection through anti-neuroinflammatory effects, and histone deacetylase (HDAC) inhibitors mitigate neurodegeneration by promoting the transcription of neuronal survival factors. We designed and synthesized a dual inhibitor, statin hydroxamate JMF3086, that simultaneously inhibits HMGR and HDAC, and examined its neuroprotective effects on

Indexed as

AnimalsDrosophilaHippocampusHistone Deacetylase InhibitorsHydroxymethylglutaryl-CoA Reductase InhibitorsLeucine-Rich Repeat Serine-Threonine Protein Kinase-2MiceMice, TransgenicNerve DegenerationNeuritesNeuronal OutgrowthNeuronsNeuroprotective AgentsParkinsonian DisordersPhosphorylationHistone Deacetylase InhibitorsHydroxymethylglutaryl-CoA Reductase InhibitorsLeucine-Rich Repeat Serine-Threonine Protein Kinase-2Neuroprotective Agentshistone deacetylaseHMG-CoA reductaseleucine-rich repeat kinaseParkinson’s diseasetubulin

Identifiers

PMID33231564

DOI10.18632/aging.104165

PMCPMC7803522

OpenAlexW3110251889

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.