Evidence map›Paper›PMID 33231508›Full record

ArticleOtolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery2021

A Comprehensive Analysis of Treatment Management and Survival Outcomes in Nasopharyngeal Carcinoma.

Khodayar Goshtasbi, Brandon M Lehrich, Jack L Birkenbeuel, Arash Abiri, Jeremy P Harris, Edward C Kuan

Abstract read
In one paragraph

Article in Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Proton Versus Photon Radiation Therapy for Nasopharyngeal Carcinoma.Journal of neurological surgery. Part B, Skull base · 2026
    Article
  4. Pituitary adenoma management and outcomes according to hospital case volume and facility type.World journal of otorhinolaryngology - head and neck surgery · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Khodayar GoshtasbiDepartment of Otolaryngology-Head and Neck Surgery, University of California-Irvine, Orange, California, USA.
Brandon M LehrichDepartment of Otolaryngology-Head and Neck Surgery, University of California-Irvine, Orange, California, USA.
Jack L BirkenbeuelDepartment of Otolaryngology-Head and Neck Surgery, University of California-Irvine, Orange, California, USA.
Arash AbiriDepartment of Otolaryngology-Head and Neck Surgery, University of California-Irvine, Orange, California, USA.
Jeremy P HarrisDepartment of Radiation Oncology, University of California-Irvine, Orange, California, USA.
Edward C KuanDepartment of Otolaryngology-Head and Neck Surgery, University of California-Irvine, Orange, California, USA.
University of California, Irvine · USUniversity of Pittsburgh · US

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Christine Hui · 1994 to 2026
$57.9M
NCI NIH HHS P30 CA062203
6 · The paper itself

Abstract

objectivesTo comprehensively investigate nasopharyngeal carcinoma (NPC) treatment, overall survival (OS), and the influence of clinical/sociodemographic factors on outcome. STUDY

designRetrospective database study.

settingNational Cancer Database.

methodsThe 2004-2015 National Cancer Database was queried for all patients with NPC receiving definitive treatment. Log-rank tests and Cox proportional hazards models were used for statistical analyses.

resultsA total of 8260 patients with NPC were included (71.4% male; 42.5% with keratinizing histology; mean ± SD age, 52.1 ± 15.1 years), with a 5-year OS of 63.4%. Multivariate predictors of mortality included age ≥65 years (hazard ratio [HR], 1.81;

conclusionsNPC survival is dependent on a variety of clinical/sociodemographic factors. Stage-specific treatments with optimal OS include CRT or RT for stages I to II and CRT for stage III to IV. The large representation of nonendemic histology is valuable, as these cases are not well characterized.

Indexed as

AdultAgedCombined Modality TherapyDatabases, FactualFemaleHumansMaleMiddle AgedNasopharyngeal CarcinomaNasopharyngeal NeoplasmsNeoplasm StagingProportional Hazards ModelsRetrospective StudiesSocioeconomic FactorsSurvival RateTreatment Outcomechemoradiotherapynasopharyngeal carcinomaNCDBNPCoverall survivalradiation oncology

Identifiers

PMID33231508
PMCPMC12582172
OpenAlexW3110321508

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.