ArticleHuman brain mapping2021
White matter hyperintensities at critical crossroads for executive function and verbal abilities in small vessel disease.
Article in Human brain mapping, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Systematic Review and Meta-Analyses of Word Production Abilities in Dysfunction of the Basal Ganglia: Stroke, Small Vessel Disease, Parkinson's Disease, and Huntington's Disease.Neuropsychology review · 2024Pooled it
- Neuropsychological differential diagnosis of Alzheimer's disease and vascular dementia: a systematic review with meta-regressions.Frontiers in aging neuroscience · 2023Pooled it
- Cerebral small vessel disease moderates the association between executive dysfunction and spontaneous neural activity in adults who lost their only child.BMC medical imaging · 2026Article
- Cognition Disconnected: The Influence of Domain-General Cognition (g) in Lesion-Deficit Mapping.bioRxiv : the preprint server for biology · 2025Article
- Disrupted Brain Structure-Function Coupling and Its Mediating Effects on the Associations Between Cerebral Small Vessel Disease Burden and Cognitive Dysfunction.CNS neuroscience & therapeutics · 2025Article
- Cognitive control & the anterior cingulate cortex: Necessity & coherence.Cortex; a journal devoted to the study of the nervous system and behavior · 2025Article
- Review
- Prevalence and characteristics of vascular cognitive impairment in a European cohort of adult patients with Moyamoya angiopathy.Journal of neurology · 2024Article
- Computational limits to the legibility of the imaged human brain.NeuroImage · 2024Article
- Article
- The volume and the distribution of premorbid white matter hyperintensities: Impact on post-stroke aphasia.Human brain mapping · 2024Article
- Blood-Brain Barrier Breakdown is a Sensitive Biomarker of Cognitive and Language Impairment in Patients with White Matter Hyperintensities.Neurology and therapy · 2023Article
- White matter hyperintensities in former American football players.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Early Subacute White Matter Hyperintensities and Recovery of Language After Stroke.Neurorehabilitation and neural repair · 2023Article
- Deep medullary veins: a promising neuroimaging marker for mild cognitive impairment in outpatients.BMC neurology · 2023Article
- Intraindividual Cognitive Variability and Magnetic Resonance Imaging in Aging American Indians: Data from the Strong Heart Study.Journal of Alzheimer's disease : JAD · 2023Article
- Cardiovascular profiles associated with white matter hyperintensities in healthy young women.Frontiers in physiology · 2022Article
- White matter hyperintensities at critical crossroads for executive function and verbal abilities in small vessel disease.Human brain mapping · 2021Article
- Imaging Markers of Subcortical Vascular Dementia in Patients With Multiple-Lobar Cerebral Microbleeds.Frontiers in neurology · 2021Article
- MRI biomarkers of small vessel disease and cognition: A cross-sectional study of a cognitively normal Mexican American cohort.Alzheimer's & dementia (Amsterdam, Netherlands) · 2021Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The presence of white matter lesions in patients with cerebral small vessel disease (SVD) is among the main causes of cognitive decline. We investigated the relation between white matter hyperintensity (WMH) locations and executive and language abilities in 442 SVD patients without dementia with varying burden of WMH. We used Stroop Word Reading, Stroop Color Naming, Stroop Color-Word Naming, and Category Fluency as language measures with varying degrees of executive demands. The Symbol Digit Modalities Test (SDMT) was used as a control task, as it measures processing speed without requiring language use or verbal output. A voxel-based lesion-symptom mapping (VLSM) approach was used, corrected for age, sex, education, and lesion volume. VLSM analyses revealed statistically significant clusters for tests requiring language use, but not for SDMT. Worse scores on all tests were associated with WMH in forceps minor, thalamic radiations and caudate nuclei. In conclusion, an association was found between WMH in a core frontostriatal network and executive-verbal abilities in SVD, independent of lesion volume and processing speed. This circuitry underlying executive-language functioning might be of potential clinical importance for elderly with SVD. More detailed language testing is required in future research to elucidate the nature of language production difficulties in SVD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.