Evidence map›Paper›PMID 33231330›Full record

ArticleJournal of clinical laboratory analysis2021

Metabolic syndrome in rheumatoid arthritis patients: Relationship among its clinical components.

Mariel García-Chagollán, Susana Elizabeth Hernández-Martínez, Alma Elizabeth Rojas-Romero, José Francisco Muñoz-Valle, Ramón Sigala-Arellano, Sergio Cerpa-Cruz, José Javier Morales-Núñez, José Alvaro Lomelí-Nieto, Gabriela Macedo Ojeda, Jorge Hernández-Bello

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical laboratory analysis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Very low-density lipoprotein and the human health.World journal of experimental medicine · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Mariel García-ChagollánInstitute of Research in Biomedical Sciences, University Center of Health Sciences (CUCS), University of Guadalajara, Guadalajara, México.ORCID https://orcid.org/0000-0001-6885-0202
Susana Elizabeth Hernández-MartínezUniversity Center for Exact Sciences and Engineering (CUCEI), University of Guadalajara, Guadalajara, México.
Alma Elizabeth Rojas-RomeroUniversity Center for Exact Sciences and Engineering (CUCEI), University of Guadalajara, Guadalajara, México.
José Francisco Muñoz-ValleInstitute of Research in Biomedical Sciences, University Center of Health Sciences (CUCS), University of Guadalajara, Guadalajara, México.ORCID https://orcid.org/0000-0002-2272-9260
Ramón Sigala-ArellanoClinical Pathology Laboratories, Civil Hospital of Guadalajara, Guadalajara, México.
Sergio Cerpa-CruzRheumatology Service, O.P.D. Civil Hospital of Guadalajara "Fray Antonio Alcalde", Guadalajara, México.
José Javier Morales-NúñezInstitute of Research in Biomedical Sciences, University Center of Health Sciences (CUCS), University of Guadalajara, Guadalajara, México.
José Alvaro Lomelí-NietoInstitute of Research in Biomedical Sciences, University Center of Health Sciences (CUCS), University of Guadalajara, Guadalajara, México.
Gabriela Macedo OjedaDepartment of Public Health, University Center of Health Sciences (CUCS), University of Guadalajara (UdG), Guadalajara, Mexico.ORCID https://orcid.org/0000-0002-3815-2160
Jorge Hernández-BelloInstitute of Research in Biomedical Sciences, University Center of Health Sciences (CUCS), University of Guadalajara, Guadalajara, México.ORCID https://orcid.org/0000-0001-8004-1811
Universidad de Guadalajara · MXHospital Civil de Guadalajara · MX

Funding

PRODEP- SEP Mexico UDG-PTC-1433
6 · The paper itself

Abstract

backgroundMetabolic syndrome (MetS) prevalence in rheumatoid arthritis (RA) patients is known to vary considerably across the world. This study aimed to determine the prevalence of MetS in RA patients from western Mexico and to analyze the interrelation of the MetS components with the clinical variables of RA.

methodsThis case-control study included 216 RA patients and 260 control subjects (CS). MetS prevalence was determined according to the NCEP/ATP III and the Latin American Consensus of the Latin American Diabetes Association (ALAD) criteria.

resultsMetS was observed in 30.6% RA patients and 33.3% of controls (p > 0.05) according to NCEP/ATP III and 28.7% in RA patients and 31.1% for controls using ALAD criteria. Total cholesterol, LDL-C, and Castelli's I-II indexes were lower in RA (p < 0.001) than in CS. The RA patients with MetS had more swollen joints than those without MetS (p = 0.018). In RA patients with MetS, DAS-28 score correlated with smoking index (rho = 0.4601, p = 0.0004) and VLDL-C (rho = 0.3108, p = 0.0056); similarly, rheumatoid factor (RF) correlated with age (rho = 0.2031, p = 0.0027), smoking index (rho = 0.3404, p < 0.0001), triglycerides (rho = 0.1958, p = 0.0039), and VLDL-C (rho = 0.1761, p = 0.0162).

conclusionsThe MetS prevalence in RA patients from western Mexico is not higher than controls; however, in RA patients with MetS, some inflammatory markers are associated with MetS components; thus, the control of MetS in RA could be beneficial to regulate disease activity.

Indexed as

AdultArthritis, RheumatoidCase-Control StudiesCholesterol, VLDLFemaleHumansMaleMetabolic SyndromeMexicoPrevalenceWaist CircumferenceCholesterol, VLDLCastelli's indexdisease activitylipid profilesmetabolic syndromerheumatoid arthritisrheumatoid factor

Identifiers

PMID33231330
PMCPMC7957969
OpenAlexW3108048193

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.