Evidence map›Paper›PMID 33231164›Full record

ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2021

Restless legs syndrome is increased in postural orthostatic tachycardia syndrome.

Caroline Dodson, Kanika Bagai, Leonard B Weinstock, Emily Thompson, Luis E Okamoto, Amanda Peltier, Satish R Raj, Arthur S Walters

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Caroline DodsonDepartment of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee.
Kanika BagaiDepartment of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee.
Leonard B WeinstockSpecialists in Gastroenterology, St. Louis, Missouri.
Emily ThompsonDepartment of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee.
Luis E OkamotoClinical Pharmacology Division, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Amanda PeltierDepartment of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee.
Satish R RajDepartment of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, University of Calgary, Alberta, Canada.
Arthur S WaltersDepartment of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee.
Vanderbilt University Medical Center · USDermatology Specialists · USUniversity of Calgary · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

objectivesPostural orthostatic tachycardia syndrome (POTS) and restless legs syndrome (RLS) are both characterized by sleep disturbance along with autoimmune/inflammatory features and autonomic dysfunction. However, to our knowledge, there has been no direct study looking at the prevalence of RLS in patients with POTS patients compared with healthy participants (controls).

methodsNinety-six physician-diagnosed patients with POTS (89 female and 7 male) and 130 controls (99 female and 31 male) were administered the Cambridge Hopkins questionnaire. Participants who were diagnosed with probable or definite RLS on the Cambridge Hopkins questionnaire were then contacted to determine the severity of RLS with the International Restless Legs Scale.

resultsMore patients with POTS (15 of 96; 15.6%) than controls (6 of 130; 4.6%) were diagnosed with probable or definite RLS on the Cambridge Hopkins questionnaire (P = .0048). A sensitivity analysis with only female respondents yielded similar results. RLS severity was in the moderate range (12.23 ± 9.22).

conclusionsThere is a higher prevalence of RLS in patients with POTS patients compared with controls. This association may have to do with shared increased inflammatory/autoimmune load and autonomic dysfunction.

Indexed as

Postural Orthostatic Tachycardia SyndromeRestless Legs SyndromeSleep Wake DisordersFemaleHumansMalePrevalenceSurveys and Questionnairesautoimmuneautonomicinflammationpostural orthostatic tachycardia syndrome (POTS)restless legs syndrome (RLS)

Identifiers

PMID33231164
PMCPMC8020678
OpenAlexW3107255586

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.