Evidence map›Paper›PMID 33231091›Full record

ArticleCell transplantation

Optimal Time to Ship Human Islets Post Tissue Culture to Maximize Islet.

Barbara J Olack, Michael Alexander, Carol J Swanson, Julie Kilburn, Nicole Corrales, Antonio Flores, Jennifer Heng, Jayagowri Arulmoli, Keiko Omori, Peter J Chlebeck and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell transplantation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Barbara J OlackIntegrated Islet Distribution Program, Department of Diabetes & Cancer Discovery Science, City of Hope, Duarte, CA, USA.
Michael AlexanderDepartment of Surgery, University of California Irvine, Orange, CA, USA.
Carol J SwansonIntegrated Islet Distribution Program, Department of Diabetes & Cancer Discovery Science, City of Hope, Duarte, CA, USA.
Julie KilburnIntegrated Islet Distribution Program, Department of Diabetes & Cancer Discovery Science, City of Hope, Duarte, CA, USA.
Nicole CorralesDepartment of Surgery, University of California Irvine, Orange, CA, USA.
Antonio FloresDepartment of Surgery, University of California Irvine, Orange, CA, USA.
Jennifer HengDepartment of Surgery, University of California Irvine, Orange, CA, USA.
Jayagowri ArulmoliScharp-Lacy Research Institute, Aliso Viejo, CA, USA.
Keiko OmoriDepartment of Translational Research and Cellular Therapeutics, City of Hope, Duarte, CA, USA.
Peter J ChlebeckDepartment of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Laura ZiturDepartment of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Mayra SalgadoDepartment of Translational Research and Cellular Therapeutics, City of Hope, Duarte, CA, USA.
Jonathan R T LakeyDepartment of Surgery, University of California Irvine, Orange, CA, USA.ORCID 0000-0001-8553-4287
Joyce C NilandIntegrated Islet Distribution Program, Department of Diabetes & Cancer Discovery Science, City of Hope, Duarte, CA, USA.ORCID 0000-0002-3001-517X
City of Hope · USUniversity of California, Irvine · USUniversity of Wisconsin–Madison · USScharp-Lacy Research Institute · US

Funding

The Human Islet Distribution Coordinating Center (UC4)UC4DK098085 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI EVANS-MOLINA, CARMELLA, NILAND, JOYCE CAROL · 2012 to 2017
$25.6M
NIDDK NIH HHS UC4 DK098085
6 · The paper itself

Abstract

Access to functional high-quality pancreatic human islets is critical to advance diabetes research. The Integrated Islet Distribution Program (IIDP), a major source for human islet distribution for over 15 years, conducted a study to evaluate the most advantageous times to ship islets postisolation to maximize islet recovery. For the evaluation, three experienced IIDP Islet Isolation Centers each provided samples from five human islet isolations, shipping 10,000 islet equivalents (IEQ) at four different time periods postislet isolation (no 37°C culture and shipped within 0 to 18 hours; or held in 37°C culture for 18 to 42, 48 to 96, or 144 to 192 hours). A central evaluation center compared samples for islet quantity, quality, and viability for each experimental condition preshipment and postshipment, as well as post 37°C culture 18 to 24 hours after shipment receipt. Additional evaluations included measures of functional potency by static glucose-stimulated insulin release (GSIR), represented as a stimulation index. Comparing the results of the four preshipment holding periods, the greatest IEQ loss postshipment occurred with the shortest preshipment times. Similar patterns emerged when comparing preshipment to postculture losses.

Indexed as

Islets of Langerhans TransplantationHumansIslets of LangerhansOrgan PreservationTime Factorsculturediabeteshuman isletsshipping times

Identifiers

PMID33231091
PMCPMC7885128
OpenAlexW3109978386

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.