SynthesisESC heart failure2021
Meta-analysis of echocardiographic quantification of left ventricular filling pressure.
Synthesis in ESC heart failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis of echocardiographic quantification of left ventricular filling pressure.ESC heart failure · 2021Pooled it
- A Hemodynamic Bridge from Echocardiography to Directly Measured Left Ventricular End-Diastolic Pressure: The Intermediate Role of Pulmonary Artery Diastolic Pressure in a Routine Catheterization Cohort.Diagnostics (Basel, Switzerland) · 2026Article
- Observational
- Echocardiographic assessment of left ventricular filling pressure compared to pulmonary artery catheter in mechanically ventilated patients: Systematic review and meta-analysis.Annals of intensive care · 2026Review
- Unmasking Left Ventricular Diastolic Dysfunction: Pathophysiology, Diagnosis, and Treatment Strategies.Medical sciences (Basel, Switzerland) · 2025Review
- CMR Left Ventricular Filling Pressure Exhibits Strong Haemodynamic Relevance and Outperforms Echocardiography in Multimodal Heart Failure Assessment.Journal of cardiovascular development and disease · 2025Article
- Evaluation of Mortality and Hospitalization Due to Decompensated Heart Failure and Appropriate Shocks in Reduced Ejection Fraction in Patients with an Implantable Cardioverter-Defibrillator According to a Novel Tissue Doppler Echocardiographic Method.Journal of clinical medicine · 2025Article
- The Prognostic Value of the Visually Assessed Time Difference between Mitral Valve and Tricuspid Valve Opening Score for Patients with Acute Heart Failure.Acta Cardiologica Sinica · 2025Article
- External validation of artificial intelligence for detection of heart failure with preserved ejection fraction.Nature communications · 2025Article
- Do we need more tools or better tools to assess congestion?ESC heart failure · 2024Article
- Pulmonary transit time is a predictor of outcomes in heart failure: a cardiovascular magnetic resonance first-pass perfusion study.BMC cardiovascular disorders · 2024Article
- Sex-specific cardiac magnetic resonance pulmonary capillary wedge pressure.European heart journal open · 2024Article
- Association of Coronary Wall Thickening and Diminished Diastolic Function in Asymptomatic, Low Cardiovascular Disease-Risk Persons Living with HIV.Radiology. Cardiothoracic imaging · 2024Observational
- Correlations of Serum Lipid Parameters and Atherogenic Indices With Left Ventricular Diastolic Dysfunction Among Apparently Healthy Patients With Type 2 Diabetes Mellitus: A Multicenter In-Hospital Cross-Sectional Study.Journal of diabetes research · 2024Article
- Novel echocardiographic markers for left ventricular filling pressure prediction in heart failure with preserved ejection fraction (ECHO-PREDICT): a prospective cross-sectional study.Annals of medicine and surgery (2012) · 2023Article
- Cardiac Magnetic Resonance Left Ventricular Filling Pressure Is Associated with NT-proBNP in Patients with New Onset Heart Failure.Medicina (Kaunas, Lithuania) · 2023Article
- Heart Failure with Reduced Ejection Fraction: The Role of Cardiovascular and Lung Ultrasound beyond Ejection Fraction.Diagnostics (Basel, Switzerland) · 2023Review
- Expert proposal to characterize cardiac diseases with normal or preserved left ventricular ejection fraction and symptoms of heart failure by comprehensive echocardiography.Clinical research in cardiology : official journal of the German Cardiac Society · 2023Review
- Effects of left atrial function on pulmonary arterial pressure in acute myocardial infarction, hypertrophic and dilated cardiomyopathy.BMC cardiovascular disorders · 2022Article
- A novel echocardiographic right ventricular dysfunction score can identify hemodynamic severity profiles in left ventricular dysfunction.Cardiovascular ultrasound · 2022Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
aimsThe clinical reliability of echocardiographic surrogate markers of left ventricular filling pressures (LVFPs) across different cardiovascular pathologies remains unanswered. The main objective was to evaluate the evidence of how effectively different echocardiographic indices estimate true LVFP. METHODS AND
resultsDesign: this is a systematic review and meta-analysis. DATA SOURCE: Scopus, PubMed and Embase. Eligibility criteria for selecting studies were those that used echocardiography to predict or estimate pulmonary capillary wedge pressure or left ventricular end-diastolic pressures. Twenty-seven studies met criteria. Only eight studies (30%) reported both correlation coefficient and bias between non-invasive and invasively measured LVFPs. The majority of studies (74%) recorded invasive pulmonary capillary wedge pressure as a surrogate for left ventricular end-diastolic pressures. The pooled correlation coefficient overall was r = 0.69 [95% confidence interval (CI) 0.63-0.75, P < 0.01]. Evaluation by cohort demonstrated varying association: heart failure with preserved ejection fraction (11 studies, n = 575, r = 0.59, 95% CI 0.53-0.64) and heart failure with reduced ejection fraction (8 studies, n = 381, r = 0.67, 95% CI 0.61-0.72).
conclusionsEchocardiographic indices show moderate pooled association to invasively measured LVFP; however, this varies widely with disease state. In heart failure with preserved ejection fraction, no single echocardiography-based metric offers a reliable estimate. In heart failure with reduced ejection fraction, mitral inflow-derived indices (E/e', E/A, E/Vp, and EDcT) have reasonable clinical applicability. While an integrated approach of several echocardiographic metrics provides the most promise for estimating LVFP reliably, such strategies need further validation in larger, patient-specific studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.